The BAU heads to St. Louis, Missouri where ten year old Andrew Taffert has gone missing. The reason it is a BAU case is that the Tafferts - father Malcolm Taffert and mother Lida Taffert - had been receiving prank calls...
The BAU team investigates a CIA counter-terrorism unit to identify a traitor who had a fellow agent murdered and who is trying to find and kill the unit's informant, a Saudi woman with two children who are in hiding.
The case of a missing boy placed up for auction online by a child pornographer draws the BAU team to work together with a former profiler who now works for the Innocent Images Unit to find the boy before the auction ends.
The BAU team investigates a series of murders in Florida, suspecting a partnership between two deviant persons with complementary personalities due to the nature of torture videos taken of the victims sent to the victims' parents.