For most of season 7, Jennifer Jason Leigh was doing a play in New York and wasn't available, so the writers came up with the idea of having her character appeared in video chat sessions. She filmed those with the director at her house of at breaks from the play.
According to Jenji Kohan, twins Amanda and Rachel Pace would be slightly jealous of each other because one was playing the twin who got to wear make-up and hair extensions, so to keep them both happy they would take turns in playing the characters.
A running sound gag is heard whenever anyone (especially Nancy) is sipping a drink through a straw. The noise heard is what one would hear when a drink has gotten so low that air begins to go up the straw. This will occur in Weeds, however, regardless of the level of the liquid.
Regular cast members Alexander Gould and Elizabeth Perkins voiced characters in Finding Nemo (2003) as title character Nemo and Coral, Nemo's mother, respectively. In season four they were joined by guest star Albert Brooks who portrays Gould's grandfather on the show but plays Nemo's father, Marlin, in 'Finding Nemo'.
FX's The Shield (2002) is mentioned as a favorite show among some of this shows characters and several guest stars from "The Shield" have had guest appearances on this show, including U-Turn and Guillermo.
The book Rejuvenile by author Christopher Noxon has appeared several times on the show. Noxon is married to series creator Jenji Kohan. Noxon was also the music supervisor for season one and appeared in the pilot episode as a bear hunter.
From season 4 to 7, the intro sequence was replaced by small clips where the viewer would see things that were prominent later on in each episode and that featured the name of the show and its creator. Every writer would come up with the one for his/her/their particular episode.
On several DVD audiocommentaries, creator Jenji Kohan reveals how the season finales of the show are influenced by some genre or specific directors she loves and thinks about when writing those episodes. Season 1 was a nod to The godfather (1972) -hence the title of the episode-; season 2 was Quentin Tarantino -the episode ends with a bunch of characters pointing guns at each other; season 3 was Robert Altman and his ensemble pieces with lots of subplots crossing; season 4 was Sergio Leone and the spaghetti-western, with big close-ups of the actors; season 5 was Pedro Almodóvar -hence the title of the episode- and season 6 was Alfred Hitchcock, which is actually why Kohan herself makes a silent cameo on the episode.
Alanis Morissette was a huge fan of the show and asked if there was any role she could play to the producers. At the same Jenji Kohan was coming up with the character of Audra, based on a real friend of Kohan also named Audra, and offered it to the actress/singer.
Lindsay Sloane was a huge fan of that show and considered the role of Maxeen perfect for the kind of role she wanted to play at that time in her career. But in retrospect she regrets taking it because she found out was pregnant the day before started shooting, and felt disconnected in the part because she was disconnected in her own body. So she thinks she didn't line up enough with what they wanted that part to be. She couldn't even be on the season finale, it which her character is written out.
Between seasons of the show, creator Jenji Kohan made a pilot called Ronna & Beverly (2009) also for Showtime, co-created with Jessica Chaffin and Jamie Denbo. The network eventually passed on the project, but Kohan not only used both actresses on Weeds, but also Olga Sosnovska, who also worked on the failed pilot. Chaffin played Cracklynn on season 4; Denbo played Raylene on season 5 and Sosnovska played Zoya on season 7.
Jenji Kohan came up with the characters of the three brothers that work with Demetri, based on the Hanson brothers of Slap Shot (1977), because Pablo Schneider wasn't available for the season 7 finale and his character's absence had to be explained somehow.
The trivia items below may give away important plot points.
Jenji Kohan said that they tried to get Justin Chatwin to reprise his role as Josh Wilson several times trough the years, but he was always booked. Knowing it was their final chance, Kohan sent a text message to Chatwin directly and asked him to be on the series finale. Having done that, Chatwin appeared only in the first and final episode.
Jenji Kohan explains on the DVD commentary that the decision of literally burning down Agrestic and move on to another story-line was due to the fact that the writers were getting bored of writing suburbia jokes. Mary-Louise Parker was particularly pleased with the idea of killing the premise of the show, as she loves risks when it comes to her acting.