For most of season 7, Jennifer Jason Leigh was doing a play in New York and wasn't available, so the writers came up with the idea of having her character appeared in video chat sessions. She filmed those with the director at her house of at breaks from the play.
A running sound gag is heard whenever anyone (especially Nancy) is sipping a drink through a straw. The noise heard is what one would hear when a drink has gotten so low that air begins to go up the straw. This will occur in Weeds, however, regardless of the level of the liquid.
According to Jenji Kohan, twins Amanda and Rachel Pace would be slightly jealous of each other because one was playing the twin who got to wear make-up and hair extensions, so to keep them both happy they would take turns in playing the characters.
Regular cast members Alexander Gould and Elizabeth Perkins voiced characters in Finding Nemo (2003) as title character Nemo and Coral, Nemo's mother, respectively. In season four they were joined by guest star Albert Brooks who portrays Gould's grandfather on the show but plays Nemo's father, Marlin, in 'Finding Nemo'.
Jenji Kohan said that they tried to get Justin Chatwin to reprise his role as Josh Wilson several times trough the years, but he was always booked. Knowing it was their final chance, Kohan sent a text message to Chatwin directly and asked him to be on the series finale. Having done that, Chatwin appeared only in the first and final episode.
FX's The Shield (2002) is mentioned as a favorite show among some of this shows characters and several guest stars from "The Shield" have had guest appearances on this show, including U-Turn and Guillermo.
The book Rejuvenile by author Christopher Noxon has appeared several times on the show. Noxon is married to series creator Jenji Kohan. Noxon was also the music supervisor for season one and appeared in the pilot episode as a bear hunter.
The trivia item below may give away important plot points.
Jenji Kohan explains on the DVD commentary that the decision of literally burning down Agrestic and move on to another story-line was due to the fact that the writers were getting bored of writing suburbia jokes. Mary-Louise Parker was particularly pleased with the idea of killing the premise of the show, as she loves risks when it comes to her acting.