The second season opens where the first season left off...Nancy Botwin, the suburban soccer mom who also happens to be the Queen of Weed in her community, has just discovered that the new man in her bed is a bona fide DEA agent, complete with gun and badge! When Conrad hears the news, he threatens to pull the plug on their deal and their friendship; In order to get into the growing business, Nancy must sell the bake shop, but a sale won't net enough cash; Silas' disrespect is getting on Nancy's nerves; Andy attempts to get into rabbinical school to avoid getting sent ...
Nancy tries to make her business plan work without Conrad; Conrad tries to find investors for his own plan, but there are no takers; Silas wants to follow Megan to Princeton; Nancy breaks things off with Peter; at a grower's convention, Andy finds the inspiration he needs for a rabbinical school essay; Celia's family boycotts her campaign photo op; Nancy finds out the real reason why Peter won't take 'No' for an answer.
Nancy literally loses her lunch when she realizes that Peter knows she is a drug dealer, but Peter assures her that he's OK with it; Shane has clogged up the plumbing in the house with his tube socks, so Andy has a talk with him about how to better dispose of his "man juice"; speaking of man juice, 1 condom + 1 safety pin = Silas' plan to keep Megan from going away to Princeton; Celia enrolls Isabelle in Boot Camp to get her ready for Fat Camp this summer, but when asked to participate, Celia pulls a muscle she hasn't used in quite a while; later, Celia finally talks ...
Nancy and the gang go full speed ahead with their growing business; Dean loses his job at his law firm; Celia is mortified when Isabelle is approached to do modeling for a plus-sized-kids' clothing line; Uncle Andy takes Shane to a massage parlor; Armenian growers give Nancy a not-so-welcome to the neighborhood; Nancy's jaw drops when she hears Silas' and Megan's news.
Nancy asks an ambivalent Peter to help her with the Armenian neighbors; much to Celia's chagrin, Isabelle is a hit with the Huskaroo Clothing folks; Celia and Nancy get into a tiff over their one-sided friendship; Andy gets called onto the carpet over Shane's massage parlor visit; Megan and her family make a decision that devastates Silas; a late-night raid in the neighborhood sends Sanjay and Andy into a panic.
Nancy buys Silas a car to help take his mind off Megan; Isabelle cuts Celia out of her management camp; Andy finally gets Yael into bed, but definitely not the way he intended; Shane likes a girl in his debate club, but doesn't know how to show it; Vaneeta is not happy with Heylia's relationship with Joseph; Conrad is not happy with Nancy's relationship with Peter, forcing Nancy to make a risky move.
Nancy rides Silas about getting a job, but she does not like the profession he chooses; an accident with a stray pit bull means that Andy doesn't need to stay in Rabinnical school to avoid being sent to Iraq; a clerical error by Dean causes Doug to lose the election to Celia; Shane wants to quit the debate team to avoid talking to Gretchen; Councilwoman Hodes wants to make Agrestic a Drug Free Zone.
The growing business is very good for Nancy and the Gang, as all of Agrestic seems to want the new "MILF Weed"; Heylia finds out that Conrad is responsible for the new flavor on the street, and she reluctantly becomes a customer; when Celia closes a dog park in her attempt to make Agrestic drug free, she makes more enemies than friends; a visit by Celia to Shane's and Isabelle's school gives Shane a chance to impress Gretchen, but at Celia's expense; Nancy is torn when Peter reveals to her that a friend is about to get squeezed.
Nancy spoils Peter's bust by warning Heylia, which does not go over well with Peter; Nancy and her family plan a birthday party for Judah; a bored Doug starts helping Celia get the hang of city politics, but things between them get even more interesting; Shane and Gretchen are officially an item; the family party is spoiled when everyone finds out that Nancy is married to a DEA Agent.
Despite helping Heylia avoid being jailed by the DEA, Heylia still makes Nancy and Conrad pay a price for shutting down her business; Nancy and Conrad decide it might be best to cut and run; Celia and Doug's affair threatens to consume both of their marriages; the arrival in town of an old flame from Alaska further complicates Andy's already screwed-up life; Nancy invites Peter over for dinner with her family, but by the end of the evening everyone's true feelings are revealed.
Nancy and Peter's relationship falls apart, and he demands that she and Conrad liquidate and pay him; Nancy and Conrad, however, make different plans of their own; Celia's Drug Free Agrestic initiative fails when all of her signs and cameras are stolen; Celia tells Dean about her affair with Doug, but she ends up out in the cold when Doug doesn't hold up his end of the deal; Nancy tries to communicate with Silas with an ax to his bedroom door, revealing lots of signs and cameras, but no Silas.
"Pittsburgh" is no doubt where Nancy wishes she was by the end of this the second season finale. It was supposed to be a simple transaction: Nancy and Conrad sell all of their MILF Weed supply to U-turn, hand the money over to Peter, then walk away; but thanks to her oldest son, Silas, an unanticipated double-cross, and a surprise visit from the Armenians, let's just say things are NOT going according to plan. Elsewhere, Shane delivers the most profane elementary school commencement address ever; Doug and Dean get into a smack-down at the graduation party over Celia; ...