Faced with the aftermath of Shane having murdered Pilar, Nancy grabs Shane and Silas and they flee the scene. Andy is then met with the decision to split town with his family or stay and fight for Audra's affection.
After hours of aimless driving, Nancy, ignoring Shane's suggestion of hiding out in Pittsburgh, hatches a plan for the family to cross into Canada. Andy is tasked with acquiring fake IDs. Silas must decide if he's willing to live on the lam. Elsewhere, Esteban must answer to authorities regarding Pilar's murder and Nancy's whereabouts.
In an effort to make money and stay 'under the radar', Nancy, Andy, and Silas acquire scab laborer jobs at an upscale Seattle hotel. Meanwhile, Shane is left to care for baby Stevie. Back at Ren Mar, Doug finds unexpected guests.
After Shane's kidnapping, Nancy attempts to get her son back by going head-to-head with Cesar in a Skee-ball "Hall of Fame" museum. Elsewhere, Andy, Silas and baby Stevie sit at a nearby diner, formulating ideas on how to help Nancy out.
Nancy decides that her family has seen enough gunslinging for a lifetime, so to lighten things up she takes them to a Montana fair. Andy and Silas enter a butter-eating contest while Doug looks after the baby and makes friends with the carneys.
After acquiring an RV, Nancy lets Andy navigate the road and he leads them to Pioneer Town, a former western movie set now turned off-the-grid scab city. While Nancy attempts to get the lay of the land, she instructs the family to set up a mobile hash making shop inside the RV. Andy and Silas work on getting laundry machines while Doug and Shane try to obtain water.
Nancy is met with yet another roadblock when baby Stevie gets sick leaving her and Andy to scramble to find a pediatrician. Meanwhile, Silas, Shane and Doug are tasked with unloading some merchandise at a kiddie concert.
Nancy, attempting to score some big cash, returns to her hometown where she takes up residence with Warren an old acquaintance. Andy and Doug try to secure information on where to locate fake passports. Meanwhile, Silas and Shane curiously dig into Nancy's past.
Nancy, trying to get herself and her family out of the country, is continually faced with unexpected guests from her past. Andy has to get creative in order to secure passports while Doug must find his own means of obtaining one. Meanwhile, Silas deals with the possibility that Lars could be his father. Shane is left to deal with Warren who is becoming unhinged.
Nancy has a tense, one-on-one, sit-down interview with Vaughn. Andy, Shane and Warren scheme to get more cash plus the passports they'll need for the family to enter Europe. Silas continues to wrestle with the fact that Lars may be his father. Meanwhile, Doug returns to Agrestic to locate his passport.
In the season 6 finale, Nancy must free herself from the grip of Esteban in order to escape the country along with her family. At the airport, Andy attempts to calm the nerves of Shane and Warren. Meanwhile, Silas must decide whether to stay with Lars or leave with the Botwins.