Doctor Tenma is a brilliant Japanese neurosurgeon who works at Eisler Memorial Hospital in Germany. He is doing well professionally and is even engaged to the director's daughter, Eva. One day, a boy with a gunshot wound to the head is brought to him.
The three doctors are found dead, while the twins are reported missing. Tenma becomes a prime suspect for the murder. The chairman reinstates Tenma as the chief surgeon. Nine years later, a suspect in Lunge's robbery investigation is operated by Tenma and can only say one sentence after waking up.
The suspect Yunkers wakes up. Lunge tries to get a confession from him but fails. The following night, Tenma comes to the hospital with a gift and finds Yunkers running away scared and chases after him to a building. Tenma finds Yunkers held at gunpoint by a man he knows.
In Heidelberg, a girl named Nina Fortner rushes to class. She is a top student and is admired by everyone. She works as a part time pizza delivery girl and also takes karate classes. Nina comes home to find a corny romantic email written to her by an unknown boy. In Koln, Tenma searches for the identity of Yohan. He finds that Yohan lived in a lot of places and went by the names Michael and Franz. A war veteran reiterates that the boy learnt French and English with ease and always wanted to hear war stories. Few days later Yohan shows up at Nina's school.
Tenma visits a Heidelberg newspaper agency. He is permitted by a reporter to look through the archives for the article about the twins' disappearance. They find that Mr.Fortner had filed a missing person's report on a boy. Meanwhile, It's Nina's 20th birthday. She goes to the school counselor to talk about her fainting. Upon recollection, Nina says that the boy made her nostalgic. She gets another email asking her to come to Heidelberg castle. Mr. and Mrs. Fortner are reluctant to share information on the report. Tenma sensing danger hurries to Heidelberg castle.
Tenma and Nina come back to the house and find that the reporter and Nina's parents are dead. They are escorted by two police officers. On the way, Tenma realizes that the officers know more things than they are letting on. He grows suspicious and jumps off a bridge to a river with Nina. The following morning, on the river bank, Nina remembers everything from her past.
Inspector Lunge visits Eva Heinemann for information on the tie. Eva says she doesn't know anything about it. Later,at the hospital, Eva confesses her love to Tenma. He doesn't reciprocate. Eva threatens him that she would tell the police about the tie. Tenma resigns from the post. After taking Eva's info, the police round up the hospital to arrest Tenma.
The Baby leads Nina to Professor Geidlitz, one of the leaders of a right-wing extremist organization. Geidlitz tells Nina about his plan to find Johan and turn him into the leader of his organization, and informs her that he needs Nina in order to do so. Meanwhile, Tenma gets into trouble when he is caught by the Baby.
General Wolf is the first person who recognized Johan's talents. Having experienced how terrifying Johan is, he asks Tenma to kill him. But Tenma threatens one of the general's subordinates and escapes to Frankfurt in order to prevent the right-wing extremists from burning down the Turkish part of town. ...
Nina is held by the police as a witness to the plan to burn down the Turkish quarter but is released when Mr. Rosso appears, the owner of a small restaurant where Nina worked after parting ways with Tenma. It's been a long time since they've met, and when Nina sees Rosso pour five spoonfuls of sugar into his coffee, she finally smiles again.
Tenma visits criminal psychologist Rudi Gillen, one of his college classmates. Gillen believes that Tenma is a serial killer with multiple personalities and calls the police to have him arrested. Furthermore, he wants to analyze Tenma as a research subject after he's been arrested...
Tenma and Dieter hitchhike to their next destination in Freiham. Mr. Jones and Leia, an older vacationing British couple, pick them up. Jones, a former police officer, is suspicious of Tenma, who is wanted by the police. But Leia is friendly, and thanks to her, the trip is peaceful. Midway, Jones reveals an unexpected reason for why the couple has come to Germany!
There is a man who lives with bodyguards in a luxurious mansion in Nice in the south of France. Nina is looking for this man, called Muller, because he is the former detective who killed her foster parents, the Fortners. After quitting the police, Muller was hired by a crime syndicate. He made a lot of money in a year and retired...
There is a murder in Hamburg, Germany, believed to be one of the multiple homicides of middle-aged couples. The BKA dispatches Inspector Lunge and other investigators to go there. Lunge tells a newspaper journalist who is eager for a scoop that the murderer is the same one who committed the previous murders, and that the murderer is Tenma...
Hans Georg Schuwald, a blind business tycoon who's infamously known as "The Vampire of Bavaria," hires a different college student each day of the week to read books to him. Karl is in charge of Tuesdays. He has approached Schuwald in order to find his mother, who was acquainted with the man...
"The Thursday Boy," Edmund, who was pretending to be Schuwald's son, commits suicide. Richard, a detective hired by Schuwald, has suspicions about Edmund's death. Meanwhile, Karl approaches a certain young man who turns out to be Johan...
Schuwald tells Richard to stop the investigation because everything has been solved. Richard has suspicions about an earlier investigation he had been asked to conduct concerning the suicide of Edmund, a boy who was thought to be Schuwald's son...
Richard is a detective who quit the police force when he shot a criminal while on duty and has run himself into ruin. But reinvestigating some unsolved cases, he begins to put his life back together. Richard also discovers that there is one person behind all of the cases...
Richard commits suicide. But Dr. Reichwein, who was counseling Richard, is suspicious of the circumstances of Richard's death and begins an investigation himself. Dr. Reichwein is attacked by hoodlums who try to interfere with his investigation...
Lotte has feelings for Schuwald's son, Karl, but lately, Karl has been busy working with his father, so he hasn't had any time for her. In the college library, Lotte meets Nina, who is doing research because she suspects that the recent events surrounding Schuwald are the work of her brother, Johan.
Dr. Reichwein gets a request from a mother to counsel her son, who hurt himself jumping off a roof. Martin doesn't tell Reichwein anything, but he reveals the truth to Dieter, who has come with Reichwein.
After an unexpected incident, Johan is hospitalized but immediately released. Johan receives a threatening letter from the prostitute who was pretending to be Karl's mother, Margot, and Johan goes to her home...
Inspector Lunge of the BKA, who is searching for Tenma, meets some Japanese people in Germany who were friends of Tenma and asks them seemingly trivial things about him, trying to get into Tenma's mind.
Tenma is hiding on top of a bookshelf in a giant library late at night. He has a sniper rife with him and is planning to shoot Johan, who will appear the next day at the tycoon Schuwald's book collection donation ceremony.
Grimmer is a freelance journalist who is investigating what happened at 511 Kinderheim. After parting ways with Tenma, he meets Reinhardt, the former director of 511 Kinderheim, who is going by the name Pedrov. Reinhardt turns Grimmer away, telling him that his experiment was successful until he quit as director.
Pedrov has been shot. Before he dies, he hands Grimmer the key to a safety-deposit box that contains the data and tapes of his old experiments. Grimmer is abducted by mysterious men who are after the key.
Grimmer, who is investigating 511 Kinderheim, has passed out after being tortured by members of the former Czechoslovakian secret police. When he comes to, he is surrounded by their dead bodies. One of the bodies is that of Zeman, a Prague police inspector.
The Czech police have turned their suspicions towards the journalist Grimmer and the young detective Suk for the murders of their former police chief and three former Czechoslovakian secret police members. Even though he is a suspect, Suk meets with Grimmer to find out the truth.
Nina doesn't know that Johan has disguised himself as her and is confused when people in the street affectionately call her "Anna." Meanwhile, Tenma and Grimmer meet with Captain Karel Lanke, a leader of the former Czechoslovakian secret police.
While searching for the sign with the three frogs, Nina is surprised that she knows the surrounding buildings and streets, but there is a shadow of fear in her memories. Meanwhile, Tenma and Grimmer get an important testimony from Lanke.
In order to get close to the tycoon Schuwald, Johan used Schuwald's mistress, Margot Langer. Schuwald thinks back to the time he visited the building with the sign with the three frogs when he went searching for Margot three years after they had parted ways.
Tenma is caught in the Czech Republic. He is moved to a police department in DÃ¼sseldorf and is questioned daily. GÃ¼nter Milch, an escape artist, is in the same detention area. When Milch feigns illness, Tenma has a look at him...
Tenma makes a false confession and places the blame on himself. He is moved from the detention area of the police station to a prison. Meanwhile, upon learning that Tenma has confessed, Eva calls the lawyer Baul to tell him that she will testify to prove Tenma's innocence.
Tenma has escaped and is headed to his lawyer Verdeman's house. There, Tenma finds a message inviting him to the Red Rose Mansion. Tenma heads to the Czech Republic while decoding the encoded memo that Verdeman's father left behind.
Nina faints at the Red Rose Mansion and is saved by Lipsky, a puppeteer. When she recovers from the temporary shock, Nina remembers everything that happened on that tragic day that the Lieberts were killed.
While acting as Eva's bodyguard, Martin becomes determined to protect Eva, even from Tenma, who is searching for Eva. But Eva has found the person she needed to find and their professional relationship is at an end.
Martin ignores the order to kill Eva and plans to escape with her. He follows the mysterious man who was with the man in glasses who hired him to his room. But as if having anticipated he'd come, the man happily begins talking about Martin's past.
Inspector Visbaugh, who was in charge of the murder cases concerning the Lieberts and the Eisler Memorial Hospital victims, is nearing retirement. His final job is to transport Dinger, a multiple homicide offender.
Nina has recovered all of her memories and goes alone to Capek's villa in search of Johan. Meanwhile, acting on a note that Milan left behind, Tenma watches Christof, the young man who works with Capek.
Johan, during his confrontation with Anna, reveals what he endured in the Red Rose Mansion as a child. As Tenma and Anna embark further on the monster's trail, Johan is already ahead of them, now knowing where his path of destruction will end.
Inspector Lunge and Grimmer are standing on a hill that overlooks the town of Ruhenheim. A disaster will soon befall this seemingly peaceful town. The townspeople will become suspicious of each other and then annihilate each other.
In the pouring rain, in the town of Ruhenheim, people have become suspicious of each other and have begun killing each other. Inspector Lunge is saving the surviving townspeople as he searches for the leader of the group that is inciting the massacre.
Inspector Lunge tracks down Roberto, the leader of the inciters, and charges in. But Inspector Lunge ends up being defeated by Roberto, who declares that he has no name. Meanwhile, upon meeting Bonaparta, Tenma goes into the town with him to end everything.
Tenma is running through the town in the pouring rain with Franz Bonaparta, also known as Klaus Poppe, in order to save Inspector Lunge, who has gone off to arrest Roberto. The boy Wim comes to them and tells them that Nina has gone to the "Vampire's House."