It took 4 hours to put the 12-pound "face" on Ryan Reynolds. When Reynolds stepped outside in full fat make-up, a fan of his came up to him and asked if Ryan Reynolds was inside. He said yes and pretended he wasn't himself.
Since the movie was filmed in Canada, many of the minor characters (as well as lead actor Ryan Reynolds) are played by Canadians. Three of the supporting actors - "Fred Ewanuick", "Mike O'Brien" and "Cavan Cunningham" were regulars on the Canadian sitcom "Corner Gas".
Ashley Scott who played Janice, the nurse Dusty was singing to at the medical center, and star Ryan Reynolds have both played DC Comics superheroes. Scott as Helena Wayne/Huntress in Birds of Prey and Reynolds as Hal Jordan/Green Lantern in The Green Lantern and Deadpool.