Ironically, David Krumholtz (who failed Algebra I twice and hated math in school) plays a mathematician, while Dylan Bruno (who graduated from MIT with a math-heavy engineering degree) plays the math-challenged FBI agent.
Diane Farr was pregnant for most of the first half of Season 3, and her character, Megan Reeves, was temporarily reassigned to Washington, D.C., to explain her absence during the second half (while Farr was on maternity leave). Because the showrunners didn't want to have to deal with the implications of Megan being pregnant and having a baby, they instead hid the pregnancy behind increasingly large folders, bags, desks, computer monitors, and finally, extras.
Navi Rawat's character is named "Amita Ramanujan", a reference to Srinivasa Ramanujan, a self-taught Indian mathematician who worked in the first two decades of the 20th century, most notably collaborating with G.H. Hardy in number theory.
The university Cal Sci is modeled on the California Institute of Technology (Caltech) in Pasadena, developing characters loosely based on a Caltech professor and students. Portions of the series have been filmed on the Caltech campus. Gary Lorden, the chairman of the math department at Caltech, consults for the show. The pilot episode was screened at Caltech as well, receiving a standing ovation at the end.
According to an interview that Rob Morrow gave to 'The Jewish Journal of Greater Los Angeles', the Eppes family was not explicitly identified as Jewish until the fifth season, when Morrow asked the showrunners to make a point of it and to include a storyline in which his character, Don, starts to explore his religion (Morrow may have forgotten that in the season four episode "Robin Hood," Charlie does mention that he is Jewish). There were some implicit references to the family's Judaism earlier than that, however, including the comment in the very first episode about Alan serving brisket on Friday nights and Don and Charlie's conversation in the Season 3 episode "Provenance" about how it was weird that their mother had wanted a Christmas tree.
When the producers prepared to pitch the series concept to the network, they prepared an elaborate presentation about the story possibilities, anticipating that the executives would wary of agreeing to such a cerebral premise. However, the network executives were immediately enthusiastic part way through the pitch that the series had good potential and insisted on production beginning immediately.
David Krumholtz grew up in Rego Park, New York and did his first commercial for a Forest Hills restaurant. Rob Morrow played Dr. Joel Fleischman from Forest Hills. Judd Hirsch played John Lacey who lived in Rego Park. Forest Hills and Rego Park are two adjoining areas in Queens New York.
David Krumholtz and Peter MacNicol previously appeared together in Addams Family Values (1993). MacNicol played a camp counselor who, in one scene, punishes Krumholtz for wanting to read a book about physics instead of doing camp activities. This is a humorous contrast to Numb3rs where the two men play best friends, and MacNicol's character is himself a physicist.
The New Yorkers: Rob Morrow, David Krumholtz, Judd Hirsch, Alimi Ballard and Diane Farr were all born in or around New York, NY. Although she was born in Fairfax, Virginia, Sabrina Lloyd's New York connection is in that she moved there in 1988, at the age of 18.
Don Eppes' Driver License is as follows: I0002074 he lives at 8111 Aguacote (which means Avacado in Spanish) Los Angeles, California 91021 he is 5'11" (180Cm) 160 pounds (73Kg) and his DOB is 7-15-1967.