The abduction of an undercover agent brings ex-CIA psychic Simon Kraft back into the Eppes' lives, and while Charlie pursues a scientific solution and Don a procedural one, Kraft's visions lead them toward an ancient ceremony and the loss of another life.
When Robin Brooks loses a case involving the murder of an informant, the team takes it very personally. Launching an investigation to get around double jeopardy, and bring justice down on an international arms dealer.
An old friend who's a DEA agent agrees to assist Liz in an undercover operation when Charlie uses math to affect the city's drug traffic, but a miscalculation and an addiction endangers both her life and the operation.
Charlie is distracted from applying math to his first basketball-coaching job when a doctor claims to have evidence that clears a death-row inmate, leaving him and the team very little time to be sure real justice occurs.
Charlie takes a very personal interest when one of CalSci's professors is murdered during a raid by animal rights advocates, and once the murderer is found Nikki's actions put the operation and civilians at risk.
A rash of apparent suicides takes a sinister turn when a gambling connection is uncovered. Elsewhere, Charlie worries when Alan's retirement disappears, and Larry flounders trying to find his new path.
The team gets a close-up look at the movie business when a producer's desiccated body is found in the desert. Elsewhere, Larry knows that he's leaving but not his destination, and Alan struggles with technology.
The team explores an odd death by some kind of electricity at a decommissioned airbase, finding themselves teamed with an odd character from the Pentagon's Department 44. Elsewhere, David ponders his future and Alan celebrates a birthday.
The team gets into a turf war with a prison warden, and the casualty may be Ian Edgerton and the member of Don's team that he's taken hostage in a desperate attempt to prove himself innocent of murder charges.
When robbers hit a diamond exchange and take hostages, Don and the team find an unlikely ally in convict John Buckley, who may help the team's investigation when they believe the men are copying Buckley's criminal strategies.
When the team foils a robbery of an armored car full of Federal Reserve money and recover bills that trace back to the infamous D.B. Cooper heist, they call on Agent Roger Bloom, who worked on the Cooper case, for help with the investigation.