During a meeting of the "MOD" squad, Polly Bailey, spokeswoman for the alcohol industry asked for advice for her upcoming appearance on "Dateline". The spokesman for the firearms industry then asked if Sawyer or Donaldson was going to do the interview. Polly Bailey replied that "Sawyer" would be doing the interview. Diane Sawyer and Sam Donaldson work for ABC. Dateline is on NBC, therefore it would be impossible for Diane Sawyer to interview Polly Bailey on Dateline NBC.
In the scene where it flashes back to Bobby Jay Bliss's youth it states he tried joining the National Guard days after the 1971 Kent State shootings. However, modern cars can be seen in the reflection of the Military Recruiter's door.
Nick tells Jeff that lighting a cigarette in a space station would cause an explosion because it's an all-oxygen environment. This is only partially correct. In real spaceships, there is a pure oxygen environment but at a reduced pressure (about 5 psi) so there is no danger of run away explosions. The Apollo I incident, where three astronauts died in a similar situation caused by an electrical spark, was a ground test and so the pure oxygen environment was about 15 psi - hence the run away fire.
During the MoD squad meeting, when Polly takes a bite of the pie she messes the cheese up, but in the next scene it's fine. Also, when Nick sees the cheese on top of the pie it is not melted, but when he pauses to think and stares at the pie, the cheese is clearly melted around the edges.
In one scene, when Nick is talking to BR, the camera switches from looking at BR to behind BR. When it is looking at BR he doesn't have his glasses on, but when the camera is behind BR, we see he has his glasses on.
When Polly is arguing with Nick about cigarettes and alcohol, in one shot her hair is tucked behind her ear. Then in the next shot her hair is covering her ear. Then in the last shots of her, Polly's hair is tucked back behind her ear.
While speaking to Senator Ortolan K. Finistirre, Dennis Miller comments that he must have the senator's tie pin which is clearly visible. The next two times that the senator is shown, his tie pin is gone. It returns the third time the senator is shown.
When Nick's ex-wife and son visit Nick after the Heather Holloway article, he first talks to his wife from behind his closed door. At this time he has stubble on his face from not shaving. When he answers the door - and for the rest of the scene - he is clean-shaved.
During the MoD squad meeting, when Polly dips a piece of bread in her food it is a short piece of bread. She lifts it to her mouth and it is a new long slice. Next shot (seen from the side), it's short again.
During the second MoD squad meeting when Bobby Jay is talking about the Boeing pilot, Polly's right hand is on the table and her left hand is high and empty. Change of camera angle and we see her lower a glass to the table.
When the "Captain" dies, Nick flies to Winston-Salem NC, to attend the funeral. As the limos are pulling in to the cemetery, you can see the following on the bumpers: TCP-54321. That could only happen in California. The CA Public Utilities Commission issues permits to operate limousines called Transportation Charter Party. Each limo has to have the letters TCP and its individually assigned number on the corners of both front and rear bumpers.
Near the end of the movie when tobacco settles with the people of America by paying $256 billion, the courtroom-type picture shown on the screen is actually from the criminal trial of Larry Nevers and Walter Budzyn, Detroit police officers accused of negligence in the death of a citizen in 1992.
At Nick's press conference in which he addresses Heather's article, in the cut scene with Heather, you see from the window that she is located in a sky-scraper. This is not possible in Washington because of the building height restrictions. Director Jason Reitman points this out during the commentary.
In one of the hospital scenes, Nick is shown with an IV hooked up to a machine on a pole behind him. The machine, however, is actually a tube feeding pump, not an IV pump. There also isn't any tubing on it, or feeding solution, or IV solution.
During the scene where Nick is talking to the press about Heather's article, as the film cuts to Heather Holloway in the office (when she drops the files while watching Nick on TV), the computer monitors on the desks clearly have no cables plugged into them, making the computers on which the other journalists are working useless.