Life goes on after the tragic deaths of Hank and Dean. Meanwhile, the Monarch deals with life "inside" but you can't keep a good criminal mastermind down. But will King Gorilla prove to be his greatest ally, or his worst betrayer?
The Monarch has escaped from prison, and the Henchmen re-assemble to serve him. Dr. Venture takes Dean to a shopping mall and the family gets ambushed by the Monarch who was there attempting to win back Dr. Girlfriend.
Molotov Cocktease fills in at the Venture compound as Brock goes on a mission to terminate a rogue agent. While Molotov tries to beat some masculinity into Dr. Venture and his sons, we learn something of Brock's past through flashbacks.
Team Venture find themselves trapped in the clutches of a bloodthirsty Egyptian cult and their time machine. Dr. Venture narrowly escapes and teams up with Master Billy Quizboy and Pete White, but promptly forgets to mount a rescue. So it's up to Brock and a pantheon of history's greatest men to find another way out.
While a mysterious extra-terrestrial Inquisitor evaluates human culture, Dr. Venture discovers an old video recording from his father informing him he must, before tomorrow night, locate and assemble the hidden pieces to a device that will save the Earth from certain doom.
Baron Underbheit returns as the Venture Bros jet crashes in Underland. The Baron seeks revenge on Dr. Venture and attempts to marry Dean, who is dressed in a Princess Leia slave girl costume when they are captured.
Gargantuan 1 crashes and Col. Bud Manstrong survives and hailed as a national hero. He and the Ventures are then honored at the White House. But the ghost of Abraham Lincoln appears suspecting an attempt will be made to assassinate the President.
While Dr. Venture constructs his Venturestien Monster, Brock has an existential crisis and a parody "Scooby Gang" arrives, looking to solve a "Mystery". Hilarity, violence, tripping on some vine juice, and a general pissing on Scooby Doo.
The Monarch proposes to Dr. Girlfriend. Thanks to the hasty actions of the Henchmen, the entire Venture family finds themselves participating in the wedding. Phantom Limb crashes the party, threatening to destroy everyone unless the wedding is called off.