Contrary to popular belief, Samuel L. Jackson's agent insisted that the title be changed, because Jackson "couldn't" work on a film with such a title. When Jackson heard about all of this, he responded with the much cited comment, "We're totally changing that back. That's the only reason I took the job: I read the title."
In March 2006, New Line Cinema, due to massive fan interest on the Internet, allowed for a five day re-shoot to film new scenes to take the movie from PG-13 to an R-rated film (originally the film wrapped principal photography in September 2005). Among these additions is the Samuel L. Jackson character's line, "I've had it with these motherfucking snakes on this motherfucking plane," a line that originated in an anticipatory Internet parody of the movie.
This film's title originated at an after-work happy hour among Hollywood colleagues to see who could come up with the most awful pitch for a movie. Producer Craig Berenson, who worked for DreamWorks at the time, gave his pitch for this movie based on a script called "Venom."
The character played by Julianna Margulies is on her last flight as a flight attendant and is leaving to become a lawyer. Julianna Margulies portrays a lawyer in the television show The Good Wife (2009).
In TV airings of the movie, the often quoted line is changed to "I have had it with these monkey-fighting snakes on this Monday-to-Friday plane!" Ironically, Samuel L. Jackson later ended up fighting monkey type creatures in both The Legend of Tarzan (2016) and Kong: Skull Island (2017).
The initial script for the film was 122 pages long, when David R. Ellis signed on to direct. After reworking the script, along with his Producing Director and Samuel L. Jackson, for more than four months, the script was narrowed down to 103 pages.