Snakes on a Plane (2006) Poster


450 snakes were used, including one 22-foot-long Burmese python.
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Contrary to popular belief, Samuel L. Jackson's agent insisted that the title be changed, because Jackson "couldn't" work on a film with such a title. When Jackson heard about all of this, he responded with the much cited comment, "We're totally changing that back. That's the only reason I took the job: I read the title."
(at around 44 minutes) When the male flight attendant puts the snake in the microwave, he can be seen hitting the 'snake' preset button on that microwave - a somewhat unusual preset for a microwave.
(at around 1 hour 26 minutes) The movie's line "I have had it with these motherfucking snakes on this motherfucking plane!" was voted as the #55 of "The 100 Greatest Movie Lines" by Premiere in 2007.
Most snakes were digitally created, because the real snakes did not move as much as the filmmakers wanted.
In March 2006, New Line Cinema, due to massive fan interest on the Internet, allowed for a five day re-shoot to film new scenes to take the movie from PG-13 to an R-rated film (originally the film wrapped principal photography in September 2005). Among these additions is the Samuel L. Jackson character's line, "I've had it with these motherfucking snakes on this motherfucking plane," a line that originated in an anticipatory Internet parody of the movie.
This film's title originated at an after-work happy hour among Hollywood colleagues to see who could come up with the most awful pitch for a movie. Producer Craig Berenson, who worked for DreamWorks at the time, gave his pitch for this movie based on a script called "Venom."
A live diamondback rattlesnake was found in a Phoenix, Arizona AMC theater during an August 2006 screening. Another rattler was found nearby in the parking lot.
(at around 1 hour 26 minutes) The phrase "snakes in the cockpit", which is said in the film, is used by pilots in reference to the high number of complex tasks they have to accomplish.
(at around 1 hour 11 minutes) When Sean mentions how hot it is, Agent Flynn responds with "I'm from Tennessee, I hadn't noticed". Samuel L. Jackson is actually from Tennessee.
Snakes are often mistakenly referred to as "poisonous". However the correct term is "venomous." Poison is ingested whereas venom is injected.
South Pacific Air Lines no longer exists, but was "re-created" (in a fictional sense) for the film. The airline began service from Honolulu to Tahiti on April 2, 1960, and folded sometime after.
The filmmakers named the large Burmese python "Kitty".
The fake working title, that was written on the clappers, was Anaconda 4.
The poster design of snakes wrapped around a plane is a reference to the caduceus, which is the symbol for medicine.
Shia LaBeouf was offered a role but turned it down.
The character played by Julianna Margulies is on her last flight as a flight attendant and is leaving to become a lawyer. Julianna Margulies portrays a lawyer in the television show The Good Wife (2009).
One of two films starring Samuel L. Jackson released in 2006 that had the word "snake" in the title, the other being Black Snake Moan (2006).
In TV airings of the movie, the often quoted line is changed to "I have had it with these monkey-fighting snakes on this Monday-to-Friday plane!" Ironically, Samuel L. Jackson later ended up fighting monkey type creatures in both The Legend of Tarzan (2016) and Kong: Skull Island (2017).
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Ronny Yu was attached to direct, speaking enthusiastically about the project, but bowed out following budget disputes and "creative differences". He was replaced by David R. Ellis.
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The initial script for the film was 122 pages long, when David R. Ellis signed on to direct. After reworking the script, along with his Producing Director and Samuel L. Jackson, for more than four months, the script was narrowed down to 103 pages.
In Aqua Teen Hunger Force: Super Birthday Snake (2003), Meatwad names his snake Nathan (Scott) Phillips; one of the lead actors in this snake-themed movie is Nathan Phillips.
Darius Jackson was a stand in for Samuel L. Jackson.
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The trivia items below may give away important plot points.

Body count: 31. (Plus 29 snakes, one dog and one cat.)
Snakes don't have ears.
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