The snakes in the cargo hold have tripped the breaker that controls the air conditioning in the passenger cabin, so Agent Flynn ventures into the hold to rectify the problem (and kill a few more snakes along the way). Meanwhile in L.A., Agent Harris (Bobby Cannavale) and Dr Stephen Price (Todd Louiso), an expert in venomous snakes, have determined from the photos of the dead snakes that many of them are from foreign countries and, thus, have been illegally imported. They pay a visit to a local snake dealer who has been known for shady dealing in the past. In attempting to flee, the dealer is bitten by a desert black snake, and the agents withhold the antivenom until he tells them how he got the snakes for Eddie Kim and made them super aggressive by spraying pheromones on the passengers' leis. They then take his anti-venom supplies to LAX so that it will be available when the plane lands. Just when it looks hopeful that things are going to work out, it is discovered that the cockpit is filled with snakes and that the co-pilot is dead. There is no one to land the plane, so flight attendant Claire (Julianna Margulies) asks the passengers if anyone can fly the plane. The only one with any flight experience, over 2,000 hours on his PlayStation 2 flight simulator, is Troy (Kenan Thompson), an old friend and bodyguard to rapper Three Gs (Flex Alexander). In order to clear the cockpit of snakes, Flynn instructs the passengers to secure themselves in their seats. He then shoots a hole in one of the cabin windows, causing the cabin to depressurize and sucking out all the snakes. When the snakes have been cleared from the cockpit, Troy takes over the controls and successfully lands the plane at LAX where anti-venom is immediately given to those who have been bitten. However, just as Sean and Flynn are about to deplane, Sean is bitten in the chest by a snake. Flynn shoots the snake, and Sean opens his shirt to reveal a bulletproof vest. Sean reminds Flynn of the first thing Flynn told him: "Do as I say, and you live," and turns the tables. In the final scene, Sean is instructing Flynn on how to surf.