On a journey to find the cure for a Tatarigami's curse, Ashitaka finds himself in the middle of a war between the forest gods and Tatara, a mining colony. In this quest he also meets San, the Mononoke Hime.
In modern Japan where the way of ninja is still practiced secretly, Recca discovers that he has a power to manipulate fire. Eventually he meets people who also has strange power, and he soon has to overcome his past and face his destiny.
It is the story and adventures of Margo, a little mouse who lives in a large tree made chalet. Small Margo has as neighbors to Adelina, a squirrel who lives in the top floor; and Jurand, a dormouse that lives in the basement.