When drug dealer Mickey mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie, accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman.
The team takes on the case of Valerie, an attractive female executive experiencing random episodes of excruciating pain. House agrees to take the case based on Valerie's looks, and while treating her, the men on the team are charmed by Valerie's beauty and personality, with Thirteen looking beyond the superficial to try to discover a link to her illness. Meanwhile, House uncharacteristically attempts to alleviate his conscience by reaching out to a former medical school colleague he wronged.
House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman's brother Marcus makes a surprise visit to the hospital.
During a day in the life of Princeton Plainsboro's Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.
House and the team take on the case of an avid blogger admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another's past. Meanwhile, Chase is coaxed into testing out the dating scene .
Physics student and his father, Artie, bring in the kid's lover Abby Nash, who nearly suffocated in foam during a planetarium lecture. The team eliminates everything except an allergy to something in her body. House presses Wilson to buy furniture as a way to express his personality.
When a newborn disappears from the nursery, Princeton Plainsboro goes on lockdown, preventing anyone from entering, leaving or moving within the hospital. While House and his team members are trapped in various parts of the building, new insights about the team's personal histories, relationships and regrets surface.
House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex.
House and the team take on the case of a woman Julia, who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam.
The team takes on the case of an ailing groom-to-be who harbors undisclosed secrets from a previous relationship. As his fiancée tries to get answers to her many questions, a frustrated team winnows down the possibilities. Meanwhile, House spends extra-curricular time with his Princeton Plainsboro colleagues, performing a karaoke rendition of a Gladys Knight & The Pips classic with Foreman and Chase.
During a session with Dr. Nolan, House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.
House and Cuddy are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.
When Della, a seemingly healthy and active 14-year-old, suddenly collapses during a skateboarding exhibition, House and his team struggle to diagnose her condition and reassure her parents who already have to cope with their son's terminal illness. After her body rejects a donor lung, and with time running out to save her life, Della's family is left with little hope of securing a new donor and faced with a seemingly impossible decision regarding the fate of both children. Meanwhile, House tries to appease an elderly father and his son at the clinic, and House and ...
When Alice, the author of a popular children's book series, inexplicably suffers from a seizure moments before an attempt to take her own life, the Princeton Plansboro team faces the challenges of evaluating both her underlying medical conditions, as well as her unstable psychological state. Unable to diagnose Alice, House becomes particularly motivated, as he's a fan of her books, and is convinced that the key to unlocking the mysteries of Alice's condition lies in the pages of her most recent novel. Meanwhile, House takes Cuddy on a double date with Wilson and his ...
When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don't improve, the team looks to the patient's medical history to unearth more about her past. Meanwhile, House gives Chase's new hire a cold welcome, and a visit from House's massage therapist forces House and Cuddy to confront the reservations in their relationship.
After a newborn experiences inexplicable breathing problems and liver failure, House and the team look at the baby's mother, Abbey's, own medical history for possible clues. When the team makes a discovery about her newborn's health, Abbey is presented with a difficult decision that could potentially affect both her baby's health and her own. Meanwhile, following Cuddy's directive, House challenges Foreman and Taub to hire a female doctor to join the team. When Cuddy asks House to babysit her daughter, both House and Wilson learn a few hard lessons in parenting.
It's election season, and in the midst of a tight campaign, an incumbent New Jersey senator's campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters in Thirteen's absence. House and the team are wary of the young doctor's lack of experience and medical perspective, but are forced to give their new by-the-book teammate a chance to prove herself. After the campaigning senator makes a surprising announcement, House and the team look to the ...
After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl's palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control's Dr. Dave Broda institutes a lockdown on the hospital and suspends House's team's ability to diagnose, Masters grows suspicious of Broda's motives and becomes convinced that the patient is suffering from a different disease. The girl's father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in ...
Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter's cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon's life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an ...