Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
House takes on a case where the patient has unexplained blackouts, and his daughter may hold the key to the diagnosis. Meanwhile, Cuddy prepares for her new arrival until there are complications with the birth mother.
A person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
An obese teenager collapses on stage, and the outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.