House must diagnose a man who became sick and experienced difficulty breathing during sex-play but all tests keep returning normal. Wilson experiences close-up what living with House is like. Clinic case: Herpes
6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean room bedroom after her boyfriend almost kisses her and discovers something on her arm.
A young woman swallows a bottle of sleeping pills - not to kill herself but to go to sleep, something she says she hasn't done in 10 days. Then her case deteriorates, but her partner is in a perfect position to help her. Meanwhile, House keeps falling asleep because living with Wilson has disrupted his sleep pattern. Cameron's mad at Foreman for swiping her ideas for a medical-journal article, and at House for letting him do it.
A young mother suffers a seizure in the bathtub with her newborn son, nearly drowning him, and although the baby survives the near-drowning, his problems are far from over. Foreman returns to work with some minor brain dysfunction, and a personality change that drives House up the wall.
A Katrina survivor, presumably the granddaughter of a famous blues singer, convinces House's friend Dylan Crandall that he is her father. When the girl is brought in with a deadly illness, House is sure the girl is faking, but Crandall wants her as his daughter and Crandall won't agree to a paternity test. As House and team try to save the girl's life, House and his conscience fight over the truth vs. his friend's real desire to take the girl in.
Richard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.
Wilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.