Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
House takes on a case where the patient has unexplained blackouts, and his daughter may hold the key to the diagnosis. Meanwhile, Cuddy prepares for her new arrival until there are complications with the birth mother.
A person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
An obese teenager collapses on stage, and the outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.
House's team resents being made complicit in a web of lies parents have told their son when he's brought in for treatment that may be related to his intersexuality. Meanwhile, no one's content that House is happy.
House is injured in a motorcycle accident. While recovering, he finds an accident victim suffering from a brain injury. House tries to prove the brain damage caused the accident, not vice versa, so he can treat the patient.
When all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.