Star bicycle racer collapses, and the team must come up with a diagnosis after the patient admits to blood doping. House and Stacy continue sparring with each other. Clinic Case: Flight attendant poisons himself with gum.
Chaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
House must diagnose a man who became sick and experienced difficulty breathing during sex-play but all tests keep returning normal. Wilson experiences close-up what living with House is like. Clinic case: Herpes
6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean room bedroom after her boyfriend almost kisses her and discovers something on her arm.
A young woman swallows a bottle of sleeping pills - not to kill herself but to go to sleep, something she says she hasn't done in 10 days. Then her case deteriorates, but her partner is in a perfect position to help her. Meanwhile, House keeps falling asleep because living with Wilson has disrupted his sleep pattern. Cameron's mad at Foreman for swiping her ideas for a medical-journal article, and at House for letting him do it.
A young mother suffers a seizure in the bathtub with her newborn son, nearly drowning him, and although the baby survives the near-drowning, his problems are far from over. Foreman returns to work with some minor brain dysfunction, and a personality change that drives House up the wall.
A Katrina survivor, presumably the granddaughter of a famous blues singer, convinces House's friend Dylan Crandall that he is her father. When the girl is brought in with a deadly illness, House is sure the girl is faking, but Crandall wants her as his daughter and Crandall won't agree to a paternity test. As House and team try to save the girl's life, House and his conscience fight over the truth vs. his friend's real desire to take the girl in.