A college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
A high school boy has hallucinations and collapses during an exam. When he does not respond to treatments, and the normal tests are negative, Foreman presents the case to House. Clinic Cases: A happy old lady.
A girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.
A detoxed sports star about to make his comeback breaks his arm due to brittle bones. Clinic Cases: Woman with leg pain; man trying to remove his contact lenses; a dentist with various issues and a hung over teenager; all in 70 seconds.
A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.