Mary Alice dies in her living room after committing suicide. It introduces her fellow friends and neighbors Gabrielle the spoiled ex model. Bree also known as the Martha Stewart on steroids. Susan the divorcee and single mother. And Lynette the mean mother with 4 loud and annoying children desperate to get back to work.
In the pilot we meet all of the characters, at Mary Alice young's funeral. Lynette's sons get in trouble by jumping into the pool, Susan tries to make something to bring to the funeral, but burns her macaroni and cheese.
The four ladies decides to organize the dinner the late Mary was organizing; Gabrielle is blackmailed by a 9 year old girl; Bree tries to hide her broken marriage; Karl returns to Wisteria Lane to discuss terms with Susan.
A break-in on Wisteria Lane leaves the neighbors feeling vulnerable; After Rex takes the kids away for the weekend, Bree finds herself bonding with Zach; Gabrielle takes drastic measures to keep Juanita oblivious to her secret.
Lynette locks horns at the twins' school with officious mom Maisy Gibbons; Susan continues to investigate the mystery of Zach's sudden disappearance; Juanita comes closer to discovering Gabrielle's dirty little secret affair.
Susan is miffed when Mike gets an unexpected house guest named Kendra; Andrew gets into a serious car accident that puts Mama Solis in the hospital; Mr. Shaw comes closer to solving who was blackmailing Mary Alice.
After Andrew accidentally runs over Juanita Solis, Bree and Rex help cover up the incident; Susan grows suspicious of Mike Delfino's real reason for moving to the street; Gabrielle questions the priest John confessed her adulterous affair.
Gabrielle decides to organize a glamorous Halston fashion show; Bree and Rex are now at odds with each other on how to punish Andrew; The police investigate the skeletal body in a toy chest that Paul Young dumped in the river, and begin to close in on his secret.
Bree finds out that Rex is cheating on her after he has a heart attack; Susan plans to take her relationship with Mike to the next level; Lynette, suspicious of her new nanny Claire, decides to secretly videotape her of her interaction with the kids.