With a gun at her side, Bree prepares to end it all now that her friends have abandoned her and her life continues to spiral further into despair; Gaby begins to suspect that Carlos may have had something to do with Detective Chuck Vance's murder; Susan makes up her mind to go to New York to become a true artist - with or without Mike; and an angry Tom cancels his plans to go to Paris with his girlfriend when Lynette confesses that she's an accomplice to murder and may soon be arrested.
With Carlos still in rehab, Gaby asks for Lynette's help in wooing a high-stakes company to sign with her husband's firm; Renee talks Bree into getting out of the house and having some fun at a pickup bar; in an attempt to ease her guilt, Susan pays a covert visit to Alejandro's family to see how they've been holding up since he went missing; and Mike discovers some inconsistencies with Ben's real estate project.
Bree's life continues to spiral as her alcohol consumption rises -- as does her lust for men; Lynette goes out on her first date since separating with Tom -- with Renee's hairdresser; Alejandro's current wife suspects foul play is afoot and has a confrontation with Susan; Gaby discovers that Alejandro's step-daughter was also abused by this wretched man; and Ben has special plans in store for Renee.
Susan is in for a shock when daughter Julie pays a visit and shows up six months pregnant; Bree's alcohol consumption and lust for men continues to dominate and ruin her life; Lynette's first sexual encounter since separating from Tom doesn't quite end in fireworks; and Gaby's attempt to sooth Juanita when she doesn't receive a Valentine's Day card from a boy she has a crush on backfires.
Susan discovers the identity of the father of Julie's baby; Orson makes it his duty to nurse Bree back to health; when Mrs. McCluskey throws Roy out of the house, Gaby takes him in and is reluctant to help get them back together when he proves to be an invaluable disciplinarian to her kids; after getting used to her alone time, Lynette is furious when Porter and Preston are evicted from their apartment and try to move back home; and Mike informs Renee of Ben's dire circumstances with a loan shark.
Susan tells Porter that she'll set up a nursery and watch over his and Julie's baby after Lynette firmly tells her son that she will not help raise her future granddaughter; Orson convinces Bree to go away with him to the Maine countryside - perhaps never returning to Wisteria Lane; Karen pleads with Gaby not to tell Roy about her condition; and good deeds never go unpunished when, after paying off Ben's loan shark, the thug sets his eyes on destroying Renee's life.
Susan convinces Mike to go to the police when she discovers that Ben's loanshark is out to get him; Gaby is justifiably concerned when Carlos exhibits some strange behavior on his first day back to work; Tom's girlfriend, Jane, drops a bombshell on Lynette during Penny's birthday party; and Mrs. McCluskey, who is suffering from terminal cancer, asks Bree to help put an end to her life.
On the day of the funeral of a beloved Wisteria Lane resident, each of the ladies thinks back on how this person had affected their lives. Meanwhile, believing that the investigation died with Chuck Vance, Bree is stunned when she is called in for questioning about the murder of Gaby's stepfather, Alejandro.