After agreeing to run away with Carlos on her wedding night to Victor, Gabby gets a call from Carlos, informing her that Edie has tried to commit suicide. One month later, Lynette tries to hide the fact that she has cancer from everyone, despite the fact she has no hair while she continues to deal with her difficult mother Stella. Meanwhile, Bree continues to hide the fact that her daughter is illegitimately pregnant by pretending to be pregnant herself. An old friend of Susan's, named Katherine Mayfair, moves back onto Wisteria Lane along with her second husband, ...
Newly pregnant Susan and Mike squabble over letting Julie go out to a party, and when Susan ventures to the party to try to bring Julie home, she gets mistaken for a stripper. Lynette bans Tom from her chemotherapy sessions, and asks a reluctant Gabrielle to sit in with her, who reveals a shocking secret about her childhood fear involving hospitals. Bree becomes more upset when she learns that Katherine Mayfair is an even better dessert cook. When Bree does some investigating in Katherine's house, she inadvertently overhears Katherine and Adam arguing about Dylan's ...
Susan and Mike throw a charades party at their house which brings out some of the worst in the attending guests. Bree inadvertently sends Susan to a rough side of town to see a gynecologist, while the very pregnant Danielle continues to grow edgy about continuing to remain in seclusion at the convent outside town. Meanwhile, Stella scores some marijuana from Andrew to make some pot-laced brownies for Lynette to rid her of the painful chemotherapy side effects. Bree tells the other housewives about what she overheard in Katherine's house and about the Mayfairs secret ...
Edie receives unexpected news from her doctor which makes her suspect that Carlos is cheating on her with Gabrielle, who has a reconnection to her former flame, John. Susan tries to act friendly with the new neighbors, a gay couple named Bob Hunter and Lee McDermett, and receives unexpected results when they mistake her highly neurotic, mental disorder as homophobia. Bree receives an unexpected baby shower, as well as an unexpected visitor: her former mother-in-law, Phyllis Van De Kamp, who immediately suspects that she's not pregnant which forces Bree to confide in ...
Battle lines are drawn between Katherine and Lynette over the vacant position of Association President when a unique piece of art shows up on Wisteria Lane, while Bree's former mother-in-law draws battle lines over Danielle's unborn child.
As Halloween approaches, Edie's biggest fear comes true when Carlos walks out on their relationship. Meanwhile, Susan discovers that Mike's father, Nick Delfino, whom Mike claimed was dead, is alive and serving a life prison term. Lynette, cranky through more chemotherapy, tries to deal with a opossum which digs up her front lawn garden. Gabrielle has an uncomfortable meeting with Victor's father, Milton, who tries to bribe her to stay married to Victor for his own political ambitions. Bob and Lee throw a Halloween costume party at their house and invite the whole ...
Lynette's estranged sisters, Lydia and Lucy, come to visit where they argue over taking in their irresponsible mother, Stella, who continues to be a nuisance to everyone. While having dinner with Susan and Mike, Bree and Orson realize they share different views on whether Danielle's newborn baby should be circumcised. On a boat, Victor confronts Gabrielle about her affair with Carlos, and she responds by throwing him into the ocean after thinking that he is going to murder her. Later, Bree informs Susan that she thinks Mike is a drug addict. Elsewhere, Dylan asks her ...
A mysterious stalker from Adam Mayfair's past, named Sylvia, shows up on Wisteria Lane. Police detectives question Gabrielle about Victor's whereabouts while Carlos argues with her about reporting Victor's attempt on their lives. Danielle's crying baby puts stress on Bree and Orson's marriage, as well as on Andrew who decides to move out. Meanwhile, Lynette has a reunion with her long-lost stepfather, Glen, over wanting to find her mother now living on the streets. Susan notices Mike is behaving strangely and soon realizes that he is still hiding his painkiller ...
Gabrielle announces to her friends that she and Carlos are going to run away together to get away from the revenge-seeking Victor now out after both of their hides. But things take an unexpected turn when a large tornado hits Wisteria Lane. Gabrielle finds herself seeking shelter in the crawlspace with Edie under her house where the bicker about the men in their lives. Bree and Orson are forced to deal with the crazy Sylvia Green who continues to pursue Adam while the hostile Katherine comes clean about their pasts. Lynnette, Tom and their kids are forced to seek ...
In the aftermath of the tornado that has devastated Wisteria Lane, Lynette's husband, Tom, and all their children survived, but Ida Greenburg didn't. Lynette decides to team with Karen McCluskey to have a private memorial service for their neighbor by scattering her ashes on a old baseball field. Meanwhile, Bree and Orson move in with Susan and Julie while their house is being repaired, only to find themselves recruiting Andrew to woo their contractor to get him to finish the damaged roof of their house, while Susan, more emotionally vulnerable and crazy then ever, ...
Lynette finds out that the twins, Preston and Porter, are responsible for starting the fire at Rick's restaurant. But the true culprit is the crafty Kayla who finally begins escalating her twisted quest to destroy the Scavo family by trickery and intimidation. While Lynette sees through the charming, but very sociopath, Kayla's nefarious plans, the naive and immature Tom, blinded by his own denial, refuses to believe that Kayla is responsible for everything bad that is happening to the family. Meanwhile, Bree gives Orson an ultimatum to turn himself in after finding ...
Gabrielle and Carlos finally learn the truth about Ellie's "work", and they also discover the police are already onto Ellie and her drug-selling ring, and have been staking out the Solis home for some time and want to use the Solis' to arrest Ellie in a sting operation. Meanwhile, Bree declares an all-out war against Edie after learning that she's now after Orson for her latest man conquest. But when Edie does something shocking involving Orson who makes the mistake of revealing the origins of Bree's baby Benjamin, Bree is forced to come clean to the rest of the ...
Susan finally gives birth to her new baby, and all of her friends on Wisteria Lane welcome the new addition to Susan and Mike's family. But Susan and Mike both begin to squabble about what to name their newborn son when Mike insists on naming him 'Maynerd' after his late grandfather, and Susan wants to name him 'Connor'. Meanwhile, Bree and Katherine do some self-defense shooting as the increasingly erratic Wayne escalated his stalking of her when he begins to suspect that Dylan is not their biological daughter. Gabrielle forms a strong bond with Ellie, who becomes ...
In the season final, several residents of Wisteria Lane are faced with deadly threats; Adam is held captive by the deranged Wayne who physically tortures him for information as to Dylan's origins... and what happened to the real Dylan Davis. Ellie, now a fugitive, contacts Gabrielle to help her retrieve a teddy bear from their house. Tom and Lee finally have their commitment ceremony in the form of a block party on Wisteria Lane. Lynette is forced to cater to the party while Tom refuses to help out because of the Kayla case. Meanwhile, Susan realizes she will soon ...