Mary Alice dies in her living room after committing suicide. It introduces her fellow friends and neighbors Gabrielle the spoiled ex model. Bree also known as the Martha Stewart on steroids. Susan the divorcee and single mother. And Lynette the mean mother with 4 loud and annoying children desperate to get back to work.
In the pilot we meet all of the characters, at Mary Alice young's funeral. Lynette's sons get in trouble by jumping into the pool, Susan tries to make something to bring to the funeral, but burns her macaroni and cheese.
The four ladies decides to organize the dinner the late Mary was organizing; Gabrielle is blackmailed by a 9 year old girl; Bree tries to hide her broken marriage; Karl returns to Wisteria Lane to discuss terms with Susan.
A break-in on Wisteria Lane leaves the neighbors feeling vulnerable; After Rex takes the kids away for the weekend, Bree finds herself bonding with Zach; Gabrielle takes drastic measures to keep Juanita oblivious to her secret.
Lynette locks horns at the twins' school with officious mom Maisy Gibbons; Susan continues to investigate the mystery of Zach's sudden disappearance; Juanita comes closer to discovering Gabrielle's dirty little secret affair.
Susan is miffed when Mike gets an unexpected house guest named Kendra; Andrew gets into a serious car accident that puts Mama Solis in the hospital; Mr. Shaw comes closer to solving who was blackmailing Mary Alice.
After Andrew accidentally runs over Juanita Solis, Bree and Rex help cover up the incident; Susan grows suspicious of Mike Delfino's real reason for moving to the street; Gabrielle questions the priest John confessed her adulterous affair.
Gabrielle decides to organize a glamorous Halston fashion show; Bree and Rex are now at odds with each other on how to punish Andrew; The police investigate the skeletal body in a toy chest that Paul Young dumped in the river, and begin to close in on his secret.
Bree finds out that Rex is cheating on her after he has a heart attack; Susan plans to take her relationship with Mike to the next level; Lynette, suspicious of her new nanny Claire, decides to secretly videotape her of her interaction with the kids.
Edie organizes a neighborhood search for Mrs. Huber, just as her sister arrives on Wisteria Lane; Bree agrees to a separation and asks an attractive pharmacist on a date; Susan's ex-husband, Karl, suddenly returns for a visit; Lynette's fears Tom is attracted to their nanny.
The residents of Wisteria Lane learn the fate of Martha Huber; Susan confesses to Edie about her role in her house fire; Bree finds George getting a little too close for comfort; Carlos is released on bail, and placed under house arrest.
When Tom's father visits, Lynette unwittingly learns a family secret; Susan is disturbed by Julie's growing romance with Zach; Rex attempts to reconcile with Bree as she tries to play hard-to-get; Gabrielle is shocked when John's parents demand her help.
Susan looks forward to a romantic date with Mike until she learns a surprising fact; Lynette's neighbor accuses her twins of thievery; Bree learns of Rex's sexual needs; Gabrielle's work adventures continue.
Mike is questioned in Mrs. Huber's murder; John's friend Justin tries to blackmail Gabrielle with his knowledge of the affair; Tom wants a big promotion, but Lynette fears she would be left alone with the kids even more: Julie learns of Zack's dark side at his pool party.
Maisy Gibbons' series of unfortunate events shocks Wisteria Lane; Gabrielle and Carlos' sewer system goes out; Lynette learns of a rumour that her twins started a head lice epidemic; Susan finds a surprising ally after her breakup with Mike.
Mama Solis' awakens from her coma, as Gabrielle and Carlos fret over their financial issues; Lynette befriends a deaf woman; Bree encounters more trouble when disciplining Andrew; Susan finds herself attracted to Edie's hunky new contractor.
Susan's mother pays an unexpected after breaking up with her boyfriend; Gabrielle faces Carlos' wrath after he learns about the hospital settlement; While babysitting Lynette's children, Bree decides to punish the twins for misbehaving; Felicia gets closer to Zach where he reveals to her more disturbing details about his family.
Lynette learns that no good deed goes unpunished when she befriends Mrs. McClusky; Susan's mother decides to try to jump-start her and her daughter's love lives; Bree forces Andrew to talk to the family priest about his conflicted sexuality.
Gabrielle plans a big party to bid farewell to Carlos and begins to suspect she's pregnant; George Williams returns, much to Rex's displeasure; Lynette learns Tom's old girlfriend, has been hired at his firm again; Susan and Julie encounter strange behavior from the Young family.
George continues to worm his way into Bree's life; Lynette tries to spice up her sex life with Tom; Susan hires Mr. Shaw to investigate the Young family; Morty proposes to Sophia, making Susan relieved her mother's moving out; Felicia takes action to help Zach by planning to drive Paul from neighborhood for good.
Susan and Mike decide to move in together; Lynette takes steps to make sure Annabel doesn't come between her and Tom; Bree comes to a realization about George; Carlos' legal problems take a turn for the worse; Martha Huber's journal falls into the hands of Susan and Julie.