The address of the building in Chicago at which Sandra Bullock lives is 1620 Racine. This would place it in the same block as the apartment belonging to Sean Connery in The Untouchables (Connery's character lived at 1634 Racine).
Simon Wyler's death date is listed as October 6, 2004. October 6 is also the birthday of Swiss architect Le Corbusier, one of the two architects mentioned as his influences when he designed the Lake House (the other is Frank Lloyd Wright).
The actual house did not exist and was built for the movie, then dismantled. In using Google Earth to see the house, enter 41.7142, -87.8901 in the window on the Fly To tab. This will take you to the center of the lake. Zoom to the clearing on the eastern shore. Then select April 29, 2005 as the date.
The location of the lake house, on Maple Lake, is located in the same Forest Preserve and is approximately 1 kilometer away from the site of the world's first nuclear reactor, CP-1, which was constructed during World War II's Manhattan Project in the Forest Preserve.