Martin Scorsese and Liv Tyler had been developing a competing project, but then Scorsese was given the green-light for The Aviator (2004), and he backed out. Liv Tyler also subsequently left.
The characters of real-life bondage photographers Irving and Paula Klaw were actually brother and sister, not a married couple as many critics erroneously reported in reviews.
The interior scene church in Florida were shot at a church in New York, on the last day of the New York shoot. The choir in the scene, according to the director, was a real New York-based choir that sounded so good that it was decided that they sounded too polished. The hymn heard in the scene was rerecorded with a choir in Nashville, Tennessee, with some non-professional singers mixed in.
The final scene, shot in Prospect Park in Brooklyn, is a re-shoot. It had originally been filmed in black and white, but it was decided that it looked too flat.
The dialog in the courtroom scenes were taken from transcripts of the real event. In addition, some of the lines Chris Bauer says, in particular the ones spoken to Lili Taylor in the courthouse waiting room, are taken directly from letters and statements in the real life of Irving Klaw.
Director Cameo: [Mary Harron] Photographer who asks Bettie to smile for the "boys."
Director Trademark: [Mary Harron] [masochistic man] In "I Shot Andy Warhol," Valerie Solanas encounters a man who wants her to stomp all over his chest. In "The Notorious Bettie Page," Bettie Page meets a man at a party who asks her if she likes stomping on men. The two men say almost the exact same things, word for word.