Much to the chagrin of his firm, Denny takes on a first-degree murder case without anyone's help, while Jerry and Katie agree to seek compensation for a woman whose husband fell under the guise of a shady lawyer who convinced him to divorce her.
A man whose sperm was used without his knowledge to impregnate a woman tries to get the court to force her to have an abortion, and Alan and Shirley are opposing counsel. Jerry defends Leigh after she is fired for hugging a student.
Denny and Alan unknowingly sleep with the same client, who is trying to block the building of a nuclear power plant. Opposing counsel is Shirley's old friend from law school, which makes Carl Sack very jealous.
Sack becomes increasingly frustrated with the firm's lawyers constantly taking on cases that don't make any money, and finds a potential new love interest to replace Shirley. Meanwhile, Denny and Alan prepare for their Coast Guard test.
Alan takes on an old hated nemesis in a case involving a shooting death after an ambush interview on a tabloid TV show. Shirley takes a case for an old friend, a troubled Vietnam veteran, who finds himself in dire straits.
Shirley pursues a court order to euthanize her father, who is in the advanced stages of Alzheimer's Disease. The residents of Nantucket petition for the right to have a nuclear weapon, and Jerry is sued by a sexy female companion.
Denny Crane falls for a rancher client who hires him to sue the FDA over cloned meat. Shirley and Alan sue the Democratic Party over pledged convention delegates switching their votes to the other candidate.
The town of Concord wishes to secede from the United States, and Alan and Denny act as opposing counsel in the case--a case that could cost them their friendship because their opposing views on patriotism and dissent.
Jerry and Katie take a case involving a 15-year-old who claims a guard raped her in a private prison, Shirley's 17-year-old granddaughter is in trouble for voting in the primary, and Alan and Denny take on the pharmaceutical industry.
Being noted as a great lawyer attracts the attention of a former girlfriend as she asks Alan to defend her husband in a murder trial, even though he still has feelings for her which compounds the case in a conflict of interest.
A judge finds out that Alan bet with Denny on the outcome of his case involving malpractice at a military hospital. Jerry takes a sperm bank to court to find out if his nephew and his new girlfriend have the same sperm donor.
Alan and Denny vacation at a dude ranch in Utah and wind up facing adultery charges, but an unlikely ally comes to their defense. Back in Boston, Shirley defends Catherine Piper, who is accused of attempting to murder her doctor.
Alan and Shirley confront their own misgivings about legalized abortion as they defend a 16-year-old Chinese immigrant who wants one. Meanwhile, Jerry faces assault charges after punching out a man in a coffee shop who ridiculed him.
Denny and Carl go to Virginia to defend a corrections officer who shot and killed an inmate during his botched execution, and Alan and Shirley defend one of Alan's old classmates who says she was fired because she voted for John McCain.
Before Alan and Denny go to the Supreme Court, they must fight an injunction to keep them from getting married to each other. Meanwhile, religious differences could threaten Shirley and Carl's upcoming wedding.