The earliest version of the game was announced for the PlayStation 2 under Resident Evil 2 (1998) (Resident Evil 2) director Hideki Kamiya. This build was eventually cancelled as a Resident Evil installment and became the title known as Devil May Cry (2001). Eventually, development was moved to the GameCube console and another build emerged. This was the first version to feature Leon from RE2. The first version shown had Leon sporting a variation of his current costume and fighting a mist-like virus. The second shown version's showed one bad guy in particular that sported a hook on one of its hands, and the logo for the game reflected this (this can still be seen in the final logo). One more version was created and cancelled before Shinji Mikami took over and transformed the title into what it is today. Of all the builds developed, only one of them was never unveiled to the public (it was the one that was being worked on right before Mikami took over). In Japan, an exclusive DVD bonus disc included with the game has footage from the second version that was made.
The Game Cube version of this game contained a glitch. After reopening a save game file, Leon's moves sideways instead of forward, but when you reset your game and reopen the same game file again, Leon walks straight again. This sideways movement glitch happens on the Game Cube edition.