When a beautiful star quarterback of the Lingerie Football League is found murdered in the locker room hot tub with traces of lidocaine in her system, the CSIs are called in to find out who wanted her dead.
When a young woman's body is found in Central Park, drained of blood and missing part of her ear, the CSIs jump start an investigation that takes them into the dark and mysterious subculture of vampirism.
The team must unravel the series of events from a wild night for a group of friends--a night which ended in four dead bodies, and a fifth person wandering the streets covered in blood and wielding an ax.
Dr. Hawkes is trapped in a cell block during a security breach orchestrated by a familiar face from CSI's past, and the only person who can help him get to safety is the death row inmate who murdered his sister.
A mother identifies her son as the attacker in a brutal assault that left her seriously injured and her husband dead. But later she recants her positive identification, and another unrelated person confesses to the crime.
The team tries to find out who is responsible for a jewel heist at the home of a powerful defense attorney. However, they soon discover that everybody who comes in contact with the jewels is turning up dead.
A married couple is led to believe that they have found their badly decomposed dead son in a car on the roof of a Wall Street building. However, further investigation reveals that the victim is one of the boy's college classmates.
As the CSIs investigate a case involving a woman who appears to have been scared to death in a supposedly haunted section of Central Park, Mac stumbles on another dead body buried nearby in the same part of the park.
After the woman who assumed Chief of Detectives Carver's deceased sister's identity turns up dead, and the evidence continues to mount, Mac begins to suspect that Carver may have been responsible for both murders.