A famous model drops dead on the catwalk. Though she is thin, the young model is very healthy. Mac, Danny, and Sheldon Hawks work together to solve the mystery. At the PD, a man gives himself up and confesses that he has just killed his doctor. However, Stella does not think he is the murderer as he cannot give her specific details of the crime.
On a trip home from work on the subway, Danny sees a body laying on the tracks. Luckily, he manages to stop the train before destroying any evidence. Mac Taylor, arriving from a Mayor's reception in his tuxedo, and Lindsay Monroe join him. Stella and Hawks investigate the death of stock broker found hanging from a noose off of the window of his fancy office. As usual, the hanging was staged as the man was strangled to death.
Danny and Lindsey investigate the death of a music promoter and enter the world of ad posting wars between up-and-coming bands. A billionaire playboy is found impaled on a billboard with a model after throwing a party for an artist.
A man is found dead in a cemetery. The wound on his chest indicates that he died from a bullet wound, yet the CSIs found nothing but small pieces of paper inside it. The second case is of a dead woman found blindfolded with her hands tied behind her back in her fancy bed. The investigation leads the detectives to a restaurant that serves exotic food such as centipedes, live octopus, and cockroaches.
A doorwoman is found dead in the water tank of her apartment. All the evidence which are readily available points to a doctor who lives in the building. However, the man swears that he had nothing to do with the dead woman. The other case is of a man found dead on a playground in Washington Heights.
The body of a woman, half eaten by beetles, is found in a museum exhibit. The only eye-witness is a young boy who refuses to talk. Danny works solo on the case of a dead urban golfer found dead on a construction site.
A man dressed as a superhero, complete with tights and a cape, is found dead. The investigator finds that he is a patient living a home for the mentally ill. As they dig deeper, they find that someone working there is illegally selling prescription drugs. The second case is off an up-and-coming football player found dead inside his hotel room. The very healthy athlete died from a small puncture wound.
A limousine driver is shot dead inside his car, while a concert by Kid Rock is happening inside. Lindsay and Danny works on the case. Mac hears of a shooting on the police radio at Stella's address. He rushes to the scene where Stella is on the ground unconscious, while her boyfriend, Frankie, is found dead. Gunshot residue confirms that she shot him.
The CSIs arrive to investigate the death of a man shot in front of his house. A woman runs towards the scene crying that the decease was her husband. Moments later, another woman also claims that she is the dead man's wife. It turns out that the three people were a committed threesome. The other case starts with the discovery of a woman dressed as a mermaid found inside the river.
The US Marines are staging a small show in Central Park. During one of their games, a young boy finds the body of a noncommissioned officer. The Marine was highly decorated having served in many campaigns. The absence of any defensive wounds is puzzling to Mac Taylor as the victim was a very strong, well trained and combat hardened Marine. The second case involves a burnt body inside a car. Facial reconstruction reveals a shocking answer. The victim a familiar face.
A man with an engagement ring turns up dead on the Brooklyn Bridge--but more than one woman could be the prospective fiancée. And a socialite dies in a penthouse with serious bruises and another man's blood on her body, and LSD in her system.
During a Blue Train rave, a young girls dies among party goers when she starts bleeding from her eyes, nose, and mouth. The CSI's believe her to be a victim of a biological attack. The investigation is further complicated when it is revealed that Hawkes once knew the girl. Further up town, a rich playboy is found drowned in his indoor lap pool with his former maid as a suspect.
The murder of a young woman in a hospital goes undetected by the hospital staff. The victim was the driver in a drunk driving accident which killed her best friend, and she had just come out of a coma.
A teenage girl is killed, and the only potential witness is her deaf mother. The case also brings back some haunting memories for Lindsey. Meanwhile, CSI also investigates the murder of a star figure skater.