A young John Doe, nicknamed 'Slick', is found lying across the rails of an underground subway. At first, he appears to have died from third-rail electrocution, but an autopsy suggests that he may have met his end by other means of electrocution. Meanwhile, Leo Whitefield is found shot dead at close range in a gallery he owns, with no sign of break in or theft, and a construction worker turns up with a fatal injury to the head.
A very small box is found on the beach with the body of a man curled nicely in it. What is amazing is that this box is only 2x2x2 feet. This leads the detectives to a circus where the man was working as a contortionist.
A body is found, wrapped in a hotel sheet, at a laundry facility prompting Taylor and Bonesara to go through a list of NY hotels to find the owner of the sheet. Messer and Burn investigates the death of a 'living statue' found in a local park against Taylor's order.
A beautiful young sports agent is struck accidentally by truck as she flees from an unknown abuser. Meanwhile, a Boston baseball fan turns up dead from internal injuries and a new confession leads Mac to reopen the case of a death row inmate helped convict.
A very skilled and famous skyscraper climber falls off the Empire State Building while attempting to scale it. Mac Taylor and Sheldon Hawks (on his first field assignment) investigate the case. In another part of the city, Stella Bonasera and Danny Messer must solve the mysterious death of a famous designer found dead, wearing his latest creation which is a bra made of diamonds. Aiden Burn works solo on a rape case.
A plastic surgeon is found dead at Grand Central Station during rush hour. He apparently died from inhaling lye. Stella and Danny investigate the death of a blind woman. Aiden is more intent than ever to solve the rape case that she does the unthinkable, an action which forces Mac to fire her.
Detective Lindsay Monroe joins the CSI team. Her first case leads her to New York's zoo, where a dead man has been found in a tiger's cage. However, it is soon stated that the man wasn't killed by the tiger, but by another person.
Detective Taylor and Lindsey Monroe delve into a murder during the Feast of San Gennaro with ties to an oil company. Detective Flack and Hawkes investigate a mysterious case of arson where a 10 year old boy dead of smoke inhalation.
A young girl lands on the windshield of the car. Her feet tells Stella that she was a dancer. Lindsay Monroe works solo on the death of an old tram driver. She soon realizes that her case is related to the first. The third case involves the death of a fish merchant. He died from a fatal wound caused by a swordfish.
A young woman gets on an elevator with an older man. When the door opens on his penthouse, he is shot by an unseen person. The girl is not hurt and the team must track her down as she is the only eye-witness of the murder. Stella and Sheldon Hawks fish a body out of a pond in Central Park. The man, however, did not die from drowning. He suffered a fatal allergic reaction.
Four men are playing poker in an apartment. When they catch a man cheating, the other men throw him out. Just a few moments later, the doorbell rings; when one of the players looks through the peephole, expecting to see the recently departed cheater, he is facing the barrel of a shotgun and is instantly killed. Meanwhile, in Central Park, a TV weather girl is found dead on the ground. Autopsy reveals that she drowned, even though there is no water near the crime scene.
A teenage boy stumbles upon a dead body in a shop full of dolls. The man was the owner of the doll hospital. The room shows signs of a great struggle with dolls scattered all over the floor. In an upscale apartment, Stella and Sheldon Hawks examine the body of a waitress who had cancer. As oppose to the other crime scene, this room is in perfect order except for a spilled can of soup.
A female roller derby dies during a game. At first glance, it seems that she was trampled to death. However, autopsy reveals that she died from heating up from the inside. The other case involves the death of a writer found in a dumpster and wrapped in an expensive rug.
Danny and Stella are investigating a murder of a billionaire in a crime scene what seems to be a bedroom but while Stella is interrogating suspects, Danny searches the room for possible evidences and Danny manage to push a button that turns the bedroom into a panic room. With Danny trapped inside the room, they have to find a way out for Danny while a murderer is at large.