Following a spray of machine gunfire, the CSI team rises from the chaos. But when one member's life is significantly changed, it proves to be the emotional motivation they need to piece together their lives and ultimately find the shooter.
While investigating the DNA from a murder scene, Hawkes discovers that the DNA is connected to more than a dozen cases over a three-state area. But does the city really have a serial killer on their hands, or is there another explanation?
When a software company executive bleeds to death on a Manhattan street, the CSIs must delve into the wet and messy world of food "sploshing" parties - where groups of people experience food in an sensual way - to find his killer.
After a body falls from the 59th Street Bridge, the CSI team finds a compass near the body pointing east, and realizes it's the third victim of the Compass Killer. Meanwhile, detective Flack, still dealing with Angell's death, goes AWOL.
Mummified remains are found in a booby-trapped Manhattan penthouse that has been closed off for more than 80 years, and Mac and Stella race against time to find the people who discovered the body, who are still trapped in the building.
When a beautiful star quarterback of the Lingerie Football League is found murdered in the locker room hot tub with traces of lidocaine in her system, the CSIs are called in to find out who wanted her dead.
When a young woman's body is found in Central Park, drained of blood and missing part of her ear, the CSIs jump start an investigation that takes them into the dark and mysterious subculture of vampirism.
The team must unravel the series of events from a wild night for a group of friends--a night which ended in four dead bodies, and a fifth person wandering the streets covered in blood and wielding an ax.
Dr. Hawkes is trapped in a cell block during a security breach orchestrated by a familiar face from CSI's past, and the only person who can help him get to safety is the death row inmate who murdered his sister.