Dr. Jane Waterleigh wakes to find herself in an obese body, having just given birth to her fourth baby, and is called "Mother Orchis" and "Mother 417" by an all-female medical staff. The other Mothers, all of whom are corpulent and much larger than their helpers, the Servitors, tell Jane that there are no men, their only responsibility is to give birth, and Mothers neither read nor write. Jane, however, remembers her past life as a physician and wife, so two policewomen try to arrest her for "reactionism." The Doctors refuse to surrender her, and send her to sick bay, then to Laura, the historian. Laura explains that all of the men died decades ago, when a Dr. Perrigan developed a virus to control the rat population, but the strain mutated, killing all male humans, but sparing females, who were immune. Now only women survive, and they are sorted at birth into four classes--Doctors, Mothers, Servitors, and Workers--and raised in learning centers. When Laura tells Jane that she will now receive an hypnotic treatment, a drug-induced amnesia to remove all of her memory, she becomes hysterical, and returns to her earlier world. She is in the office of Dr. Hellyer, her boss and the Chief of Staff at her hospital, who reminds her that she volunteered to test a new narcotic, Sonadrin, which apparently took her to the fantastic matriarchal world from which she just escaped. She discovers that Dr. Perrigan is a real biologist, who is working on a myxomatosis strain to exterminate brown rats. She meets Perrigan and tries to convince him to discontinue his project, but he refuses, so she shoots him, lights a fire using all of Perrigan's research notes, and burns down his laboratory. She is tried for murder, but refuses to plead insanity, and insists that her sacrifice is worthwhile, since she is saving humanity from a terrible future. Then her attorney, Max Wilding, tells her that Perrigan has a son, another Dr. Perrigan, who promises to complete his father's work.
—Lewis Amack