A high school kid named Graham develops an ability which makes people worship him to the point of sacrificing their lives for him. Tom visits Isabelle in jail, hoping to get information on the whereabouts of Alana who's been missing for months. Marco calls Diana to let her know that her sister April has promicin and is nowhere to be found. NTAC gets a new director. Kyle meets a young woman named Cassie who has some advice about how to get Shawn out of his coma. Jordan shows up to deal with the high school kid.
Diana returns from Spain. NTAC tries to identify the person whose ability makes people's worst fears come true. Shawn returns home from the hospital and his brother Danny tells him that he's thinking about taking promicin. Kyle finds out some interesting facts about Cassie.
After taking promicin, an old lady named Audrey Parker develops the ability to astral project from her body. When she's murdered, her spirit tries to reach Tom and Diana to help them find her killer. Shawn decides to re-open the 4400 center and start healing again despite the government's warnings. Ben and Maia come to Seattle to visit Diana. Cassie leads Kyle to some interesting information.
Diana catches her sister April, who has survived a promicine shot and gained an ability the full potential of which she fails to grasp - to make anyone answer truthfully to any question posed by her. She has teamed up with a man she loves and they are blackmailing people who have dirty secrets. But then they bite more than they can chew and April's beloved gets murdered. The only way to get the people responsible to answer for their crimes would be for April to turn herself into NTAC custody and lose her precious freedom... Meanwhile, Shawn decides to run for the ...
Now that he knows Kyle is Promicin Positive ("P+"), Tom sets out to track him down. His journey leads him to a town that is no longer on the map and the people of which are not ordinary. Meanwhile, Maia has terrible visions of 4400s and P+es being dragged to prison camps. And her visions always come true.
The NTAC nerd squad bring to their Director's attention a 4400, Curtis Peck, who was a shoestring budget film maker and continues to be one, except that his 4400 ability seems to be to receive script pieces that combine to tell the true, complete answers to haunting questions, like "What happened to Jimmy Hoffa?" and "Who shot JFK?". And now he's missing and he left a video message where he told that Jordan Collier is not the real threat - there is something far more dangerous, and now they are after him. Peck's producer shows a trailer of the film Peck was supposed ...
Shawn gets bad publicity when he ends up having sex with the daughter of a woman whom he cured and it turns out to be a trap when the girl tells the media her story. Maia paints a vision that at first doesn't make sense, but then the nerds at NTAC match it to the most polluted - and more crucially, abandoned - part of Seattle, making it the perfect hiding place for Collier, his 4400s and P+es. Tom and Diana try to investigate, but find out that Collier has set an uncrossable perimeter around his "Promise City". When Collier starts broadcasting live footage of a P+ ...