The actors had to go through motion capture acting in order to animate the characters. The actors had to wear motion capture suits with little dots glued on their faces and a headpiece glued to their head with motion capture dots. After they took off their suits, the glue would cause irritation to their hair and scalp, but luckily they'd get a head massage with shampoo.
Homages to various Stephen King stories abound. The idea of a house that comes alive and eats people can be found in the third installment of King's "Dark Tower" series, "The Wastelands." And while in the house's basement, Chowder shines his flashlight on a mechanical monkey much like the one found in King's short story "The Monkey," collected in "Skeleton Crew."
Screenwriter Dan Harmon wasn't happy with the final product. He claimed that Director Gil Kenan and Steven Spielberg made the movie scarier than what it intended and claimed that their adding of Constance's soul taking over the house and attacking people made no sense. His friend Kelly Oxford's daughter Salinger was very scared by the film, so Harmon wrote her an apology letter saying that Kenan was a "hack" and Spielberg was a "moron". The letter ended with "And next time Monster House is on, just remember that the guy that wrote it told you it was dumb."
The tape Elizabeth plays upon entering DJ's house is marked "Skull n Bones Live". She is also wearing a Skull n Bones band tee. Her boyfriend's name is "Bones". She also mentions that he is in a band. Jon Heder's character is "Skull", suggesting that he and Bones may be the members of the band that she is listening to.
There is a back story involving Skull (played by Jon Heder) and Bones (played by Jason Lee) being in an amateur heavy metal band. When we first meet Zee (played by Maggie Gyllenhaal), she is wearing a top with "Skull 'n' Bones" written on, and later puts one of their cassette tapes on called "Live! at the Smell". She is also dating Bones in the movie.
Many people have questioned how three sticks of dynamite could cause the house to have a catastrophic explosion shown in the film. What many people forget is that Mr. Nebbercracker had stockpiled tons of explosives in the house, and those exploded when the dynamite exploded.