Auditions were held for the part of Emily because director John Polson hoped he would be able to "find another Dakota Fanning". Among the hopefuls were AnnaSophia Robb, but in the end, Dakota Fanning herself was cast.
For the first time in 70 years, 20th Century Fox shipped prints of Hide and Seek (2005), without the final reel, which would be shipped separately. This was done as a security measure as so people wouldn't be able to reveal the final ending. To further ensure the safety of protecting the film's ending, security guards would hand-deliver the reel to theaters showing the film. Fox had individually numbered each reel as well as a final security measure. Fox executive VP and sales manager Richard Myerson stated it was "to ensure everyone's enjoyment of the film and to prevent 'spoilers', we've instituted extraordinary measures. We think it's worth the effort."
At the dinner scene where Emily is presented books, the top book is Charlotte's Web. Dakota Fanning would play Fern Arable, the main human character, in the live-action adaptation of the story, Charlotte's Web (2006).