After arresting a dangerous man on the run, Jess and Nicole find a man shot in the head hanging on to life in the trunk of the car he was trying to steal. The man has amnesia and doesn't remember anything. The bullet leads the team to believe that he's connected in some way to the disappearance of young heiress Victoria Farlow and they must decide if "John Doe" is innocent or guilty while trying to figure out his identity and the circumstances of his near-death.
Antonio's ex-wife Anna's sister is kidnapped and his involvement in the case opens up intense emotions between him and his ex-wife. But once the case is successfully resolved, Antonio puts closure to the personal relationship as well.
A married woman goes missing. Her suspicious husband becomes a quick suspect in the kidnapping but as Jess and Nicole probe into her past, they discover a shocking secret and are amazed to learn that the woman had created a new life for herself. A breathtaking climax in a strange house with a very disturbed man and his "family" reveals an unbelievable secret. Meanwhile, Jess dreams about a coffin and a wedding/funeral and has troubles with a boyfriend who has a very strange name.
A mother and her young children witness a middle-aged woman being kidnapped in a parking lot. Jess has a vision while trying to corner a suspect that nearly lets him get away. The agents discover that the woman was trying to be as anonymous and invisible as possible and they learn a horrifying secret that hits too close to home for Nicole, who reveals a deadly secret about her childhood. Meanwhile, Antonio encourages Nicole to share what's bothering her and Jess is asked out by Colin, the undercover agent she worked with previously.
Jess has a vision that leads her and Nicole to discover a 10-year-old skeleton. When the body is identified, Pollack orders them off the case. Jess and Nicole continue to work on the case while trying to keep their work away from Pollack and trying to figure out why he's so insistent that they can't work on it. Meanwhile, Pollack's wife Janice kicks him out.
The agents search for a wealthy businessman who disappeared from his hotel. They try to get the truth out of his girlfriend Melody, who discovered him missing in the middle of the night. When Pollack's team is ordered off the case by his boss, he risks his job to continue working on it. Meanwhile, Pollack tries to reconcile with his wife.
Dylan Anders, a convict about to go on trial for murder, kills two police officers and escapes. He then steals a Dr. Laurel Bennett's car and kidnaps her. Jess, Nicole, Antonio and Janey are assigned to the case and Jess and Nicole eventually rescue Dr. Bennett from a burning building. Meanwhile, Nicole urges Jess to get to know Janey better and the three women urge Antonio to keep his job instead of taking a new job in airline security. Back on the case, the mystery only begins and it is eventually learned that Dr. Tanner is helping Anders instead putting the FBI off...
Federal prosecutor, Beth Duncan, who worked on a hate crime is abducted while attending her daughters 'green belt' ceremony. Issue of race come up in this case as the team sifts through a long list of criminals with motives. Eventually, Jess and Nicole rescue the prosecutor, but wind up killing her abductor in the process. But, for Beth, the kidnapper is ultimately proved innocent in the original crime for which she had him convicted for.
When the teenage perpetrator of a high school hostage crisis disappears, the agents solicit some unusual help from their suspended boss, John Pollock, to investigate the school psychiatrist's records. Then, when another student goes missing, suspicion falls on the mysterious Patient X.