In the mid-21st century, the Hemaglophagic virus (HGV), an obscure virus
from Eastern Europe which was being used to breed stronger and faster soldiers,
escaped the laboratory. Once infected, people have a lifespan of about 12
years, but first they are reduced to "hemophages" (aka "vampires"). They take on many characteristics including extended eyeteeth, regeneration, accelerated reflexes and increased strength.
One of the victims is Violet Song jat Shariff [Milla Jovovich]. Because she was infected
while pregnant, Violet was secured to a holding camp to be studied. Most of the
other hemophages have been wiped out, thanks to the actions of Vice cardinal
Ferdinand Daxus [Nick Chinlund], who is determined to wipe out every last hemophage. But the
hemophages aren't going to be led like sheep to their slaughter. Hemophages
have united, and their resistance and terrorist attacks have become known as
"the Blood War."
It is 12 years later. The scientists terminated Violet's pregnancy, and
she has managed to escape the camp and join the Hemophage Underground. After
infiltrating the Archministry by posing as courier XPD154, Violet finds herself
in possession of a case that contains the ultimate weapon against Hemophages,
one that will wipe out the entire hemophagic population. When ordered by her
Hemophagic superior, Nerva [Sebastien Andrieu], to destroy the case without opening it, which will
set off a bomb that will destroy everything a block around, Violet refuses to
comply and opens the case to discover it contains a child. It is both a weapon
and a child, she is told. The child contains antigens that will wipe out all
existing Hemophages. What is Violet to do...destroy the weapon or protect the
The child is a ten-year human named Six [Cameron Bright], because he is a clone of eight.
He has been raised all his life in a laboratory and knows very little about
life outside. Violet takes Six to be examined by her Hemophagic friend Garth [William Fichtner],
who learns that Six has only eight hours to live and that he is outfitted with
a tracking device, so Violet must keep moving lest Daxus catches up with her.
Unfortunately, Nerva has made a deal with Daxus and learned that Six doesn't
contain an antigen against Hemophagia but against the entire human race, so
Nerva seizes Six with the idea of using him against the humans. Violet sets Six
free again. In the time they have left before Six dies, Violet takes him to the
park. When the time comes, Violet is at his side, but Daxus and his henchmen
show up to claim the body and kill Violet.
Fortunately for Violet, Garth manages to retrieve her body before Daxus's
incendiary team can destroy it. After several hours of surgery, Garth is able
to bring Violet back to life. Violet goes into a deep depression but recovers
when she senses that Six is not dead and that he needs her help to get away
from Daxus. Violet storms the Archministry just as Daxus is about to saw into
Six's brain. Violet single-handedly wipes out everyone in the Archministry
except for Daxus. As they face each other, Daxus tells Violet the truth about
himself...he is actually a Hemophage, too. Violet defeats him with a flame pistol and her sword.
Epilogue: Violet carries Six to the roof and reawakens him. Six is surprised to
still be alive; a flashback reveals one of Violet's tears at the park protected him from dying by giving him immunity to what was killing him. He tells Violet that there is a cure for Hemophagia.