As promised, Lucas, Brooke, Nathan, Haley, Peyton and their Tree Hill gang meet up after 4 years of being apart. Haley and Nathan still live in Tree Hill with their now 4 year-old son, James Lucas Scott. Nathan's dreams of being a NBA star were smashed. Peyton has just quit her job in the record industry. Brooke is living in New York. Her multi-million dollar clothing line, Clothes Over Bros, has given her a successful career in fashion design. Lucas comes back Tree Hill with his new girlfriend, Lindsay, suffering writer's block. The group rekindles to see how much ...
Everyone is settled in as they come back to Tree Hill. Its the day of Jamie's box car race. Haley tries to make Nathan go to the event. While, Brooke gets frustrated, as she rekindles with Lucas, tangles over Jamie's race car outfit, and struggles on the fact of what kind of lifestyle she wants. Peyton starts a friendship with a girl who lives in her old home, and moves in with Brooke. Lucas and his girlfriend Linsday, also come to the fact that 2 of his ex's from his past, are back into town.
Haley tries to encourage a student, who is a troublemaker, to join the Ravens. Nathan goes and vists Dan in prison, without Lucas aware. Brooke is edgy after her manager, tracks her down in Tree Hill. Peyton finds new talent for the reopening of Tric, with the help of Haley. Lucas lets Peyton be the manager of Tric. Linsday, Lucas's girlfriend is worried after meeting Brooke and Peyton.
Brooke buys Karens Cafe, and turns it into a Clothes Over Bro's boutique. Everyone goes to the opening of the store, including Brooke's Manager mother, who has seemed to track her down. Lucas and Peyton cause friction at the opening.
In a flashback of three years into the past, an event between Lucas and Peyton changes their relationship forever. Brooke has to decide about the fate of her fashion line since Victoria is putting pressure on her. Whitey has doubts about Nathan as he has a sudden temper problem before a championship game because of Haley who is trying to find the balance between her school and motherhood.
Nurse Carrie isn't just an ideal playmate for Jamie, who has nightmares since Skillz told him too much about Dan. Her charms should make Haley jealous, but she doesn't realize yet that Carrie really lusts for the hunky husband. Mouth is deputized by the night-shift to ask for better working conditions from their boss Alice; he actually may earn a TV reporter spot as her "play thing". Peyton clashes instantly with Brooke's bossy mother, Victoria, who scares her new label's only star, Mia, and calls Brooke too dumb to run the fashion business herself. Lucas considers ...
It's a Tree Hill reunion as the entire gang gathers at Tric to see musical group The Honorary Title perform. Victoria turns up at the club which infuriates Brooke. Meanwhile, Brooke sets up her assistant Millicent with Mouth but Alice ruins the set-up for him by threatening to have him fired if he kisses Millicent. Peyton arranges for Mia to sing at Tric and Lucas proposes to Lindsay which stuns Peyton.
Lucas proposes to Lindsey and Peyton is the first one to know the news. Haley is upset at Lucas and Peyton for witnessing their kiss before he proposed to Lindsey. Next day Lindsey shows her ring to Haley and Brooke. Mouth finds out that Alice has been fired for sleeping with an unnamed employee and continues to pursue Millicent and finally wins her over when they watch a televised ballet recital. Carrie continues in the pursuit of Nathan and Brooke is intrigued by Owen and wants to get to know him better but cannot understand why he doesn't respond to the instant ...
It's the first game of the season and it's Mouth's big chance to impress with his coverage of the game. Meanwhile, Haley, Brooke, Peyton, Lindsey and Mia get locked in the Tree Hill High library and a lot gets said particularly between Lindsey and Peyton. Elsewhere, Nathan and Lucas endeavor to tell both Haley and Lindsey about their indiscretions.
Brooke invites Tric bartender Owen to come and see her business in New York but finds model Rachel, a friend from her past, in her apartment having taken an overdose. With Owen's help they manage to persuade her to enter a treatment program. Nathan and Lucas attend Dan's parole hearing while they try to protect Jamie from him. Mia gets an offer from Peyton's former employer. Elsewhere, Haley and Nathan's marriage is on the rocks as Carrie does her damnedest to split them up leading. Jamie falls into the pool.
Missing daddy gives Jamie nightmares about Dan, who is indeed paroled. Lucas and Lindsay decide to 'coincidentally' have separate stag and hen nights at the same place, so Nathan and Haley are bound to meet. Brooke arranges a hot blind date for Peyton, but the joke is on her: unsuspecting Owen's chosen mate is Chase, Brooke's former 'clean teen' lover. Jamie's tireless efforts to get her reconciled with her father make Haley realize she shouldn't have tried to change Nathan. Ruthless business adviser and absent mother Victoria pushes Rachel out, to Brooke's disgust.
Lindsay's big day, the wedding to Lucas, has finally arrived. The old gang reunites, remembering their own loves and/or marriages, even Karen and Andy from New Zealand. Haley still isn't ready to let Nathan back. At the altar Lindsay finally realizes the Comet in Lucas' book refers to Peyton's car and their first love, and runs out. Crazy Carrie kidnaps Jamie, pretending she was rehired as his nanny. Because Haley saw Dan and refused him entry, Nathan sends the police look for his dad. In fact Dan followed Carrie and finds his grandson.
Brooke is visited by an adoption agency and has an interview to find out if she would be a suitable mother. Lucas flies out to see Lindsey who says she will edit his novel. Dan gets Jamie back and bonds with him at School. Nathan and Haley have a good counseling session and decide to take up their hobbies of basketball and music again. Peyton is visited by Max and still has feelings for Lucas.
The marriage counselor's advice to reconnect with personal aspirations is followed to the letter. Haley is happy to re-enter the music field; Peyton is to sign her up for a record. Haley can't find an appropriate nanny, apart from Nathan's mother Deb. Nathan's come-back in basketball is harder to get going as the team's stupid star Q is rude and hostile. Only Jamie get's on with Dan, the brothers warn him to keep his distance. Brooke is ecstatic to be 'getting a baby', so she stocks up on toys etc.
It's Jamie's fifth birthday, and a grand event for the gang. Lucas hoped Lindsey, who also attends, will go back to him, but she insists on leaving her key as she leaves for New York. Although he was the one one Jamie explicitly asked to be invited, Dan isn't even allowed to hand over his personal present. However he has another for Nathan, and a heavy reason to give it. Meanwhile Brooke learns the parenting joy can drown in rivers of tears and noise, and Millicent's entry in the boys flat proves hard to adjust to.
Lucas confronts Dan's announcement about his life expectancy of only 6 months without a heart transplant. He calls Dan a liar until the cardiologist confirms it. Nathan wrestles with his feelings, and Jamie's burning desire to get acquainted with his 'cool' grandfather, while Dan begs for a last chance to repair his shattered family. Nathan and Jamie come up with a daring alternative for the injured Ravens. Mouth suddenly gets a triple break as sports presenter.
Brooke has to deal with giving up her baby Angie. Haley's career takes a turn for the better and Peyton is visited by somebody from her past. Meanwhile, Dan awaits a new heart as Lucas makes a decision on who he wants to be with. Elsewhere Mouth makes the decision to move to Omaha when Millicent agrees to go with him.