The trivia items below may give away important plot points.
Peter Webber wanted Mikael Persbrandt for the role of the soldier who eats Hannibal Lecter's little sister, but Persbrandt had at that time already signed on for another film, and was busy with a play in Sweden.
While Lecter injects himself with sodium thiopental, he plays Johann Sebastian Bach's "Goldberg Variations" in the background, the same music that plays during his escape in The Silence of the Lambs. The recording was made in 1955 by Glenn Gould. In the other movies featuring Hannibal Lecter, Gould's 1981 recording is used.