In the opening scenes when Max is waking the D.E.B.S. up, she yells at Dominique because she has a boy in her bed. In the commentary on the DVD, Meagan Good mentioned that the guy in Dominique's bed was a guy that she had actually been on a date with before they started filming the movie.
Lucy Diamond's license plate is "ndasky", probably referring to the Beatles' song "Lucy in the Sky with Diamonds". The character was referred to as "Lucy in the Sky" in an earlier draft of the script and in the short film this feature was based on.
The boy cleaning his teeth at Endgame was originally going to be smoking a joint, but it was changed to keep the PG-13 rating. However, the shot of him running into the ballroom wasn't re-shot, and you can still see the smoking joint in his hand.
When Amy, Lucy, Janet and Scud are driving to the off-limits club Scud asks Janet if she went to Dalton. Janet replies yes. Dalton is the name of a real well known private school on the upper East side of Manhattan.
The trivia item below may give away important plot points.
When Scud is returning all of the money Lucy stole electronically, there are three recipients listed. The organizations Lucy stole money from are (or at least include) The Girl Scouts of America, The Rotary Club of Lodi, and the Terre Haute Bookmobile.