George Clooney suffered a spinal injury during a stunt. Due to the weight he gained for his role, the injury left him bedridden for a month and caused severe migraines, which prevented him from doing publicity for Ocean's Twelve. The injury was eventually corrected with surgery. Clooney has since called his weight gain "pretty stupid".
In the days leading up to the Oscar nominations, the Academy announced that the film's screenplay was considered original, not adapted. Since it had been strongly advertised as adapted, many believed the film would not be nominated. It was nominated for Best Original Screenplay, but lost to Crash.