Much of the supporting character's would later make guest appearances on other shows created by series creator Dan Schneider. Examples include Craig and Eric making a small appearance in the iCarly episode "iStart a Fan War" and Helen made a special guest appearance in the Victorious episode "Helen Back Again".
In the "Really Big Shrimp" movie, one of the movie titles shown playing at the Premiere Theater where Josh works is "Lil Lisa 22", a reference to Zoey 101 (2005)'s character Michael Barret's nickname for his girlfriend.
The scene where Drake and Josh are working at a sushi conveyor belt was inspired by the famous American show, I Love Lucy (1951). It was based on the episode where Lucy and Ethel are working at a chocolate conveyor belt.
Walter's car throughout the series is a royal blue Ford Mustang convertible that seems to change to a newer model every season. In Season 1 it is a 2004 model but by Season 4 it switches to the newer 2007 body style.