The series revolves around two teenage stepbrothers, Drake Parker and Josh Nichols, who live in San Diego, California with Drake's biological mother and younger sister Megan; and Josh's biological father. Drake is a popular musician idolized by his schoolmates. Josh is a well-read student, but is clumsy and has trouble with his social life and dating. The two teenagers are often involved in comedic escapades and challenges while also handling an array of teenager problems.