Some surgery scenes had to be edited because they were just too gory. Real plastic surgeons have remarked that plastic surgery isn't as gory as this series makes it appear, but that's just for show purposes.
A medical advisor approves the authenticity of all surgical procedures on the show. None of them are real, even though they often appear that way. Whenever anyone said they looked real, the makeup people were flattered.
With this series, Ryan Murphy wanted to explore the superficiality of plastic surgery. He initially avoided setting the show in Los Angeles because he didn't want celebrities to make guest appearances. But the practice eventually did move to LA in Season 4.
Joely Richardson left the series in season 4 for to be with her family in England. Although she was listed as part of the main cast in the intro, she only appeared in 18 of the 41 episodes of season 5 and 6.
In the season 2 finale, titled "Joan Rivers" Julia compares Ava (Famke Janssen) to a Phoenix. In the X-Men comics, the character of Jean Grey (also played by Famke Janssen in the movies) turns into a creature named Phoenix.
Some of the cast/guest stars starred in films based on Marvel comics: Julian McMahon played Victor Von Doom in "Fantastic Four" and it's sequel "Fantastic Four: Rise of the Silver Surfer". Sanaa Lathan played Vanessa Brooks in "Blade". Famke Janssen played Jean Grey in the "X-Men" films. Peter Dinklage played Dr. Bolivar Trask in "X-Men: Days of Future Past". Bradley Cooper provided the voice of Rocket Raccoon in "Guardians of the Galaxy". Kate Mara played Susan Storm in "The Fantastic Four". J.K. Simmons played J. Jonah Jameson in the "Spiderman" films and Wayne Knight played Micro in "Punisher: War Zone".
Matt McNamara beds Vanessa Bartholomew and Ava Moore. Famke Janssen (Ava Moore) played Jean Grey in the "X-Men" movies in 2000, 2003, 2006, 2013 and 2014 and Kate Mara (Vanessa Bartolomew) played Susan Storm in 2015's "The Fantastic Four". The films are based on Marvel comics.
The series could had ended with the death of Matt McNamara. Instead of leaving on a plane with Ava Moore. It could had ended with Matt being murdered by Christian or Matt commits suicide, when Ava tells him she doesn't really love him.
The trivia items below may give away important plot points.
Ryan Murphy told Bruno Campos from the beginning that Quentin Costa was going to be the Carver, so Campos could play subtlety every scene with that in mind. In fact, every time the Carver appears, Campos is wearing the costume.
In season 5 when Sean and Christian appeared in Hearts and Scalples, they insist on producer credits and the occasional line, this was an inside joke after producer Linda Klein, a producer, also stars as nurse Linda with the occasional line