In the quest to create a panda-breeding program, Siegfried and Roy import one of the few remaining male pandas to the secret garden for an intimate rendezvous with the community's romantically challenged female panda Foo-Lin. However, when Larry and Kate play matchmaker in order to speed up nature, they end up disrupting the complex process of panda-mating.
Settling into the fame of his new position as lead lion, Larry looks forward to his debut in the show until Siegfried and Roy proclaim to Matt Lauer during their appearance on Today (1952) that they will unveil the greatest magic trick that the world has ever seen with their new star. Panicked over the pressure, Larry turns to the crafty veteran performer, Sarmoti, to help prepare him. However, when the trick backfired during practice, a concerned Siegfreid and Roy turn to their proven veteran white tiger Blake to save the day much to the disappointment of Larry and Sarmoti.
With the entire secret garden in a frenzy over the arrival of famed animal actor Donkey in town shooting a commercial, local celebrity Larry speaks to Hunter's class for career day. However, when his classroom performance falls flat, Larry attempts to wow his son's friends by promising a visit from his alleged good friend Donkey. Meanwhile, alarmed by the appearance of a small family owned bed-and-breakfast on the Vegas strip, Siegfried and Roy vow to take up the fight to help maintain corporate America's stranglehold on Sin City.
While dining at the Mirage with her family and Siegfried and Roy, Sierra discovers a political prisoner when she meets Emerson the lobster who as survived countless dinners in the hopes of getting his political message out to the masses. Hoping to regain his daughter's affections, Larry frees Emerson from his bondage only to regret his act of kindness based on the lobster's quest to bring down the watering hole. Elsewhere, Siegfried and Roy prepare for the arrival of Barbra Streisand and Sarmoti attempts to bond with Hunter.
Searching for a way to satisfy Kate's desire for spontaneity, Larry relies on his natural instincts and steals Blake and Victoria's big screen television. However, while this new life of crime heats up their love life, the lions find themselves in the midst of an animal dragnet. A distraught Siegfried and Roy search for the perfect gift for their white lions in the hopes of preventing the performing big cats from feeling slighted by the magician's recent showering of gifts on the tigers. Sarmoti teaches Hunter how to be an African warrior lion.
Overworked and feeling the strain of being lead lion, Larry takes advantage of a bad landing during practice to over-emphasize a leg injury, giving him a week of bed rest. However, when his blissful time off is interrupted by Sarmoti's bitterness, the exhausted lead lion slips his surly father-in-law a medicated meatball in the hope of quieting the African lion.
Kate decides that she wants to run for president of the PTA. However, she finds a problem when she saying something speciest to a turkey. Kate then has to try to make amends with the turkeys. She realises that keeping Larry and Sarmoti in line with the turkeys will be even harder then she thought.
Siegfried and Roy think it is a wonderful idea to have Sarmoti move in with his daughter, Kate, and her husband, Larry, much to the dismay of the lions. When he arrives at his new residence, he brings in his pride and joy, a zebra that he killed made into a rug. Kate finds herself destroying the rug in a fit of rage, and panics when she has realised what she has done.
Despite vowing never to forget his wedding anniversary which corresponds with Jimi Hendrix's birthday, Larry once again fails to celebrate this important occasion with Kate. However, when Siegfried and Roy's decision to whisk all the female cats off to a spa weekend at Little Bavaria prevents him from properly apologizing, Larry ventures off into the vast Nevada desert to find his wife with no one but the ever-criticising Sarmoti to aid him in this quest.
Larry remembers about how he became the main lion in the show, and how Sarmoti lost the position. He recalls how Sarmoti was extremely arrogant, and didn't want to accept not being in the limelight anymore.
When a new magic duo enter the Vegas scene, Siegfried and Roy decides to make a movie about their lives. Larry and his friends are preoccupied with their "Bill Murray marathon", leaving Kate to join Foo-Lin in a women's group session.