This is Dustin Hoffman and Lily Tomlin's first movie together, although the two of them were the original choices for Popeye and Olive Oyl in the Robert Altman film Popeye (1980).
Gwyneth Paltrow was originally attached to star as Dawn Campbell, but dropped out due to the death of her father. Nicole Kidman then attached herself to the project, but could not fit the movie in due to her schedule for The Stepford Wives (2004). At that point, Jennifer Aniston was looked at for the part until finally Naomi Watts, director David O. Russell's original first choice, was a lock.
Britney Spears also auditioned twice for the role of Dawn Campbell.
Many theater managers mistakenly wrote the film's title on marquees and in showtime listings as "I Love Huckabees". This is most likely because on all promotional material and in the film itself the title is written with a heart symbol instead of the word "heart".
Bernard Jaffe (Dustin Hoffman)'s watch face has no hands and no numbers; it is completely blank.
In Albert Markovski's "Open Spaces" office, there is a picture of Henry David Thoreau, the American Transcendentalist philosopher.
Arkansas Governor Mike Huckabee did not care for the movie, stating "It was as if somebody forgot to give the actors a script and said, 'For the next two hours, just go out there and do something.' "
The Spanish title of the film literally translates to "Strange Coincidences".
In March 2007, two videos appeared on the Internet showing on-set arguments between David O. Russell and Lily Tomlin. In one video, during filming of the office scene, Tomlin was annoyed at his direction and Russell snapped, calling Tomlin several foul names and even went so far as to knock over parts of the set. Dustin Hoffman can be seen walking away, hoping not to get involved. In the other video, while filming a scene in a car, Tomlin screams obscenities at Russell and gives him the middle finger. She also screams at Hoffman and Naomi Watts when they ask her to continue the scene. The car scene is not in the film.
An existential detective couple is featured in Thomas Pynchon's 1990 novel, "Vineland".