Ben Stiller mentioned while on a talk show promoting the film that the ferret bit him a couple of times during production, including one time latching onto his chin.
The green flag on Leyland Van Lew's yacht features the 'boxing kangaroo' which was flown from Australia II during the 1983 America's Cup campaign in which Australia was successful.
The building Leland van Lew jumps off of in Los Angeles is the AT&T Tower (611 W. 6th Street), designed by William L. Pereira in 1969 as the city's tallest skyscraper.
According to an interview, Jennifer Aniston stated that the reasons she worked on this film was both to work with her friend Ben Stiller and to dance the salsa.
In the beginning of the movie after Lisa and Reuben are wed they fly to the St. Barts airport. The aircraft shown landing at the airport lands on the "displaced thresh-hold" and not on the actual area of the runway designated for landing. Displaced thresh-holds at airports are used for taxiing and allow more room for take off but are not available for aircraft to land on.