A water treatment plant supervisor disappears, and detectives discover that he is running from his old life in Arizona, where he may have been involved in a robbery and the disappearance of one of his friends.
A prominent congresswoman disappears on a boating trip, and is later found dead. The investigation suggests that it may be related to her vote on a controversial offshore drilling deal, but Jack is positive that her husband is involved.
A young woman disappears after her boyfriend is killed in a police shooting. Agents believe the disappearance is connected to the girl's brother, a notorious gang leader who had a falling-out with her.
When a serial killer eludes capture in Nevada and escapes with his son to New York City, the crew picks up the trail with the help of Las Vegas CSI's Gil Grissom. Part two of a crossover with "CSI: Crime Scene Investigation."