Jack and the team investigate the disappearance of a 12-year-old autistic boy who ran away during a class trip to a museum. His father, Daniel Norville (VINCENT ANGELL), chaperoned the outing. Jack is suspicious of Daniel, who was seen yelling at the boy before he went missing.
Jack and the team investigate the disappearance of Rosie Diaz (ELIZABETH PEÃ±A - "Down and Out in Beverly Hills," "La Bamba"), a postal employee. When her truck is found abandoned and emptied of the $12,000 worth of videogames Rosie was delivering, the team wonders whether she is a victim of foul play or a willing participant in the theft.
Jack and the team investigate the disappearance of Chelsea Prince, a 23-year-old society girl known for her constant partying and headline-grabbing escapades. Her badly beaten limousine driver recounts how the limo was ambushed and Chelsea was taken.
Martin is wracked with guilt when he fails to prevent Mike (MASAM HOLDEN), a 12-year-old boy, from being dragged into a car outside of the boy's school. Encouraged by Martin's description of the kidnapper, Brian Stone (DYLAN BAKER - "The Elizabeth Smart Story," "Kinsey"), and his vehicle, the team tries to ease Martin's anguish over failing to stop the boy's abduction, even though he jogged by Mike and the kidnapper just moments before the crime occurred.
Jack and the team investigate the disappearance of Stephanie (SANDRA NELSON), a singer in a church choir. Stephanie's choir director informs the agents that the missing woman had been unusually emotional at the last choir practice and requested to perform a particular hymn on Sunday but then failed to show up to sing it.
Vivian takes time off from work to deal with her health problems and tries to act brave before her family and colleagues. Her deeply concerned team members attempt to focus on their case of a missing psychic, Agnes (ALEXANDRA LYDON - "24").
When a 13-year-old girl goes missing after choosing to investigate the age-old murder of a different teenage girl - taking suspicion off of the original suspect and placing it on her own father instead - the team races against the clock to find out what happened to Daisy and if her father, who turns out not to be so innocent, truly plays a part in both his daughter's disappearance and of the murder of Amber Bryce, a years-ago unresolved case.
The team helps Danny search for his missing, estranged brother, Rafael "Rafi" Alvarez (ALEX FERNANDEZ), a recovering drug addict and ex-convict who Danny grimly suspects may have lapsed into his illegal and destructive past habits.
An old man estranged from his wife and two daughters goes missing after last being seen ready to jump from the roof of his building. Jack gets personally involved in the case and trying to find the man.
As Vivian undergoes open-heart surgery, Jack and the team search for a missing woman who may be the innocent victim of an identity theft ring. But further investigation reveals that she is linked to international terrorists plotting the assassination of a foreign dignitary.
The team searches for missing 15-year-old Ryan Wallace who was obsessed with the safety of his school after losing a parent and watching the towers on 9/11 fall. Martin and Vivian both return from medical leave. Jack seems to be feeling protective of his staff and loses his temper when Danny puts himself in the way of unnecessary harm.
The backpack and ID of missing college coed Skye Petersen are suddenly dropped off at a thrift store seven years after Jack--and ultimately the legal system--determined she was murdered by her married professor with whom she'd just ended an affair.
Jack and Danny head to Mexico to find wealthy American vacationer James Costin who was abducted, at the request of James' mother-in-law. While Vivian, Sam, Martin and Elena work the case back in New York, Jack encounters resistance from the locals. The team soon becomes suspicious of James's wife Lucy Costin, convinced she knows more about her husband's disappearance than she is saying.
When the team investigates the disappearance of a man, they find pictures of child pornography in his home office and on his computer - all of the same little girl. However, the man who initially appears to be a pedophile on the run quickly becomes a helpful aid with the good intent of finding this little girl who has been subjected to a life of human trafficking and child prostitution.
This unique episode, told from the point of view of the missing person's parents, expresses the emotional anguish of the mother and father of a missing 15-year-old boy as the team does its best to find him.
Jack's friend Max Cassidy vanishes after leaving a message on his wife Anne's voice-mail. While investigating, Jack realizes that Max was having an affair, and that he has got in much deeper into an espionage case than he should have following the murder of his partner, Jimmy, a man Max had felt was too green for undercover work. Both Jack and Ann fear the worst as the team try to find Max.